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    Tbc1d17 TBC1 domain family, member 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292886, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tbc1d17provided by RGD
    Official Full Name
    TBC1 domain family, member 17provided by RGD
    Primary source
    RGD:1309686
    See related
    EnsemblRapid:ENSRNOG00000020191 AllianceGenome:RGD:1309686
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Orthologous to human TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 126.6), Kidney (RPKM 115.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d17 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104461266..104469615, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95324770..95333156, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100836993..100845216, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene VRK serine/threonine kinase 3 Neighboring gene activating transcription factor 5 Neighboring gene nucleoporin 62 Neighboring gene interleukin 4 induced 1 Neighboring gene AKT1 substrate 1 Neighboring gene polynucleotide kinase 3'-phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Fuchs E, et al. J Cell Biol, 2007 Jun 18. PMID 17562788, Free PMC Article
    2. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106258.2 → NP_001099728.1  TBC1 domain family member 17

      See identical proteins and their annotated locations for NP_001099728.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160880
      UniProtKB/TrEMBL
      A0A8I6ARY2, A6JAS9, B1H264, F7F3L4
      Related
      ENSRNOP00000027436.7, ENSRNOT00000027436.8
      Conserved Domains (2) summary
      pfam12068
      Location:3 → 218
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:308 → 543
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104461266..104469615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104825.2 → XP_038960753.1  TBC1 domain family member 17 isoform X1

      UniProtKB/TrEMBL
      F7F3L4
      Related
      ENSRNOP00000106881.1, ENSRNOT00000126829.1
      Conserved Domains (2) summary
      smart00164
      Location:308 → 517
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:7 → 205
      DUF3548; Domain of unknown function (DUF3548)

    2. XM_063283976.1 → XP_063140046.1  TBC1 domain family member 17 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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