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    Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 [ Mus musculus (house mouse) ]

    Gene ID: 11438, updated on 4-Jan-2025

    Summary

    Official Symbol
    Chrna4provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, alpha polypeptide 4provided by MGI
    Primary source
    MGI:MGI:87888
    See related
    Ensembl:ENSMUSG00000027577 AllianceGenome:MGI:87888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EBN1; Acra4; ENFL1; Acra-4
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Contributes to acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic signaling. Located in external side of plasma membrane. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in kidney adult (RPKM 15.0), whole brain E14.5 (RPKM 7.5) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Chrna4 in Genome Data Viewer
    Location:
    2 H4; 2 103.54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180664104..180685339, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181022311..181043579, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ARF GTPase activating protein 1 Neighboring gene collagen, type XX, alpha 1 Neighboring gene potassium voltage-gated channel, subfamily Q, member 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine binding  
    contributes_to acetylcholine receptor activity  
    contributes_to acetylcholine receptor activity PubMed 
    enables acetylcholine receptor activity  
    enables acetylcholine-gated monoatomic cation-selective channel activity  
    enables acetylcholine-gated monoatomic cation-selective channel activity PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity  
    enables acetylcholine-gated monoatomic cation-selective channel activity PubMed 
    contributes_to heterocyclic compound binding  
    enables heterocyclic compound binding  
    enables monoatomic ion channel activity PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables quaternary ammonium group binding  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    Items 1 - 25 of 41
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation PubMed 
    involved_in DNA repair  
    involved_in acetylcholine receptor signaling pathway  
    acts_upstream_of_or_within acetylcholine receptor signaling pathway PubMed 
    acts_upstream_of_or_within behavioral response to nicotine PubMed 
    involved_in behavioral response to nicotine  
    acts_upstream_of_or_within calcium ion transport PubMed 
    involved_in cognition  
    involved_in excitatory postsynaptic potential  
    acts_upstream_of_or_within exploration behavior PubMed 
    acts_upstream_of_or_within inhibitory postsynaptic potential PubMed 
    acts_upstream_of_or_within locomotory behavior PubMed 
    involved_in membrane depolarization  
    acts_upstream_of_or_within membrane depolarization PubMed 
    acts_upstream_of_or_within membrane depolarization PubMed 
    involved_in monoatomic ion transmembrane transport  
    involved_in monoatomic ion transmembrane transport  
    acts_upstream_of_or_within nervous system process PubMed 
    involved_in nervous system process  
    involved_in neuromuscular synaptic transmission  
    acts_upstream_of_or_within neuronal action potential PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    acts_upstream_of_or_within regulation of dopamine secretion PubMed 
    acts_upstream_of_or_within regulation of membrane potential PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system PubMed 
    involved_in response to acetylcholine  
    involved_in response to hypoxia  
    involved_in response to nicotine  
    acts_upstream_of_or_within response to nicotine PubMed 
    acts_upstream_of_or_within response to nicotine PubMed 
    acts_upstream_of_or_within response to nicotine PubMed 
    involved_in response to nicotine  
    involved_in response to oxidative stress  
    acts_upstream_of_or_within sensory perception of pain PubMed 
    acts_upstream_of_or_within sensory perception of pain PubMed 
    involved_in signal transduction  
    involved_in synaptic transmission, cholinergic  
    acts_upstream_of_or_within synaptic transmission, cholinergic PubMed 
    acts_upstream_of_or_within synaptic transmission, cholinergic PubMed 
    involved_in synaptic transmission, cholinergic  
    Items 1 - 25 of 41
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex  
    part_of acetylcholine-gated channel complex PubMed 
    part_of acetylcholine-gated channel complex PubMed 
    part_of acetylcholine-gated channel complex  
    is_active_in cholinergic synapse  
    located_in dendrite  
    is_active_in dopaminergic synapse PubMed 
    is_active_in dopaminergic synapse PubMed 
    located_in external side of plasma membrane PubMed 
    located_in membrane PubMed 
    is_active_in neuron projection  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in postsynaptic membrane  
    is_active_in postsynaptic specialization membrane  
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane  
    part_of protein-containing complex  
    is_active_in synapse  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit alpha-4
    Names
    a4 nicotinic receptor
    acetylcholine receptor alpha 4 neural
    acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit
    alpha4 nAChR

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416868.1NP_001403797.1  neuronal acetylcholine receptor subunit alpha-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL450341
      UniProtKB/TrEMBL
      B7ZBU7
    2. NM_015730.6NP_056545.3  neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_056545.3

      Status: VALIDATED

      Source sequence(s)
      AL450341
      Consensus CDS
      CCDS17192.1
      UniProtKB/Swiss-Prot
      O70174, Q8BHE9, Q8VI10, Q9ET51
      UniProtKB/TrEMBL
      B7ZBU7, Q53YK0
      Related
      ENSMUSP00000066338.8, ENSMUST00000067120.14
      Conserved Domains (2) summary
      pfam02931
      Location:39245
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:252620
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180664104..180685339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246772.2XP_030102632.1  neuronal acetylcholine receptor subunit alpha-4 isoform X2

      Conserved Domains (3) summary
      cl28912
      Location:166
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
      pfam02932
      Location:74441
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
      pfam05350
      Location:257344
      GSK-3_bind; Glycogen synthase kinase-3 binding
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