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    Emp2 epithelial membrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 13731, updated on 4-Jan-2025

    Summary

    Official Symbol
    Emp2provided by MGI
    Official Full Name
    epithelial membrane protein 2provided by MGI
    Primary source
    MGI:MGI:1098726
    See related
    Ensembl:ENSMUSG00000022505 AllianceGenome:MGI:1098726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XMP
    Summary
    Enables integrin binding activity. Involved in several processes, including early endosome to late endosome transport; embryonic process involved in female pregnancy; and protein localization to cell surface. Acts upstream of or within positive regulation of integrin-mediated signaling pathway. Located in Golgi apparatus; apical plasma membrane; and cell surface. Colocalizes with cytoplasmic vesicle; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; endometrium; medulla oblongata lateral wall; respiratory system; and sensory organ. Used to study placental insufficiency. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in lung adult (RPKM 388.0), bladder adult (RPKM 33.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Emp2 in Genome Data Viewer
    Location:
    16 A1; 16 5.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10099613..10131832, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10281749..10313968, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40073 Neighboring gene ribosomal protein L39-like Neighboring gene activating transcription factor 7 interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_40074 Neighboring gene STARR-seq mESC enhancer starr_40076 Neighboring gene predicted gene, 24667 Neighboring gene STARR-seq mESC enhancer starr_40077 Neighboring gene predicted gene 1600 Neighboring gene predicted gene, 30724

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding PubMed 
    enables integrin binding PubMed 
    enables kinase binding  
    enables kinase binding  
    enables protein kinase binding  
    enables protein kinase binding  
    Items 1 - 25 of 52
    Process Evidence Code Pubs
    involved_in T cell mediated cytotoxicity PubMed 
    involved_in actin filament organization  
    involved_in actin filament organization  
    involved_in actin-mediated cell contraction  
    involved_in actin-mediated cell contraction  
    involved_in activation of protein kinase activity  
    involved_in apoptotic process  
    involved_in apoptotic process  
    involved_in bleb assembly  
    involved_in bleb assembly  
    involved_in blood vessel endothelial cell migration  
    involved_in blood vessel endothelial cell migration  
    NOT involved_in caveola assembly PubMed 
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell adhesion  
    involved_in cell migration  
    involved_in cell-matrix adhesion  
    involved_in cell-matrix adhesion  
    involved_in early endosome to late endosome transport PubMed 
    involved_in embryo implantation PubMed 
    involved_in embryo implantation  
    involved_in embryonic process involved in female pregnancy PubMed 
    involved_in heart formation PubMed 
    involved_in membrane raft assembly PubMed 
    involved_in natural killer cell proliferation PubMed 
    involved_in neutrophil migration PubMed 
    involved_in plasma membrane raft assembly PubMed 
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of cardiac epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell-matrix adhesion PubMed 
    involved_in positive regulation of integrin-mediated signaling pathway  
    acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of integrin-mediated signaling pathway PubMed 
    involved_in protein localization to cell surface PubMed 
    involved_in protein localization to cell surface  
    involved_in protein localization to cell surface  
    involved_in protein localization to plasma membrane PubMed 
    involved_in regulation of angiogenesis  
    involved_in regulation of angiogenesis  
    involved_in regulation of cell-matrix adhesion  
    involved_in regulation of cell-matrix adhesion PubMed 
    involved_in regulation of endothelial cell migration  
    involved_in regulation of endothelial cell migration  
    involved_in regulation of glomerular filtration  
    involved_in regulation of glomerular filtration  
    involved_in regulation of kinase activity  
    involved_in regulation of kinase activity  
    involved_in regulation of vasculogenesis  
    involved_in regulation of vasculogenesis  
    Items 1 - 25 of 52
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in apical part of cell PubMed 
    located_in apical plasma membrane PubMed 
    NOT colocalizes_with caveola PubMed 
    located_in cell surface PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    colocalizes_with cytoplasmic vesicle PubMed 
    colocalizes_with membrane raft PubMed 
    located_in membrane raft PubMed 
    located_in membrane raft  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    colocalizes_with plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    epithelial membrane protein 2
    Names
    EMP-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007929.2NP_031955.2  epithelial membrane protein 2

      See identical proteins and their annotated locations for NP_031955.2

      Status: VALIDATED

      Source sequence(s)
      AC154311, AK077260
      Consensus CDS
      CCDS37250.1
      UniProtKB/Swiss-Prot
      O88662
      UniProtKB/TrEMBL
      Q548I4, Q8CGC1
      Related
      ENSMUSP00000077466.5, ENSMUST00000078357.5
      Conserved Domains (1) summary
      pfam00822
      Location:1165
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10099613..10131832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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