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    Mettl5 Methyltransferase like 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40096, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mettl5provided by FlyBase
    Official Full Name
    Methyltransferase like 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0036856
    Locus tag
    Dmel_CG9666
    See related
    AllianceGenome:FB:FBgn0036856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9666; Dmel\CG9666; Dromel_CG9666_FBtr0074991_mORF
    Summary
    Enables rRNA (adenine-N6-)-methyltransferase activity. Involved in rRNA methylation. Located in cytoplasm. Is expressed in embryonic hindgut; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mettl5 in Genome Data Viewer
    Location:
    76A3-76A3; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19263766..19266838)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19256866..19259938)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45210 Neighboring gene nessy Neighboring gene Blocked early in transport 1 Neighboring gene Max Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aldehyde dehydrogenase 7 family member A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dmp8-Dmp18 bicistron messenger RNA enables unusual translation during cellular stress. Bucio-Mendez A, et al. J Cell Biochem, 2019 Mar. PMID 30270456
    2. Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. Liu M, et al. G3 (Bethesda), 2015 Nov 6. PMID 26546310, Free PMC Article
    3. Max-independent functions of Myc in Drosophila melanogaster. Steiger D, et al. Nat Genet, 2008 Sep. PMID 19165923
    4. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
    5. Characterization of gene expression regulated by human OTK18 using Drosophila melanogaster as a model system for innate immunity. Spresser CR, et al. J Genet, 2008 Aug. PMID 18776638

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 19265613-19265735 mobile_element_type = transposon:INE-1{}4714

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA (adenine-N6-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (adenine-N6-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methyltransferase like 5
    Names
    CG9666-PA
    CG9666-PD
    Mettl5-PA
    Mettl5-PD
    NP_001137973.1
    NP_649098.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19263766..19266838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144501.2 → NP_001137973.1  methyltransferase like 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137973.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSW4, Q9VVX7
      Conserved Domains (1) summary
      COG2263
      Location:7 → 209
      COG2263; Predicted RNA methylase [General function prediction only]

    2. NM_140841.3 → NP_649098.2  methyltransferase like 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649098.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSW4, Q9VVX7
      Related
      FBpp0074759
      Conserved Domains (1) summary
      COG2263
      Location:7 → 209
      COG2263; Predicted RNA methylase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSW4.1 Q8MSW4

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