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    CG9674 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39878, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9674provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036663
    Locus tag
    Dmel_CG9674
    See related
    AllianceGenome:FB:FBgn0036663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9674; GS
    Summary
    Predicted to enable glutamate synthase (NADH) activity. Predicted to be involved in ammonia assimilation cycle and glutamate biosynthetic process. Is expressed in adult head and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9674 in Genome Data Viewer
    Location:
    73C4-73D1; 3-44 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16787573..16807731, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16780673..16800831, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit e Neighboring gene nudC Neighboring gene uncharacterized protein Neighboring gene Tumor susceptibility gene 101 Neighboring gene kuduk

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene network underlying the glial regenerative response to central nervous system injury. Kato K, et al. Dev Dyn, 2018 Jan. PMID 28791751
    2. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Willoughby LF, et al. Dis Model Mech, 2013 Mar. PMID 22996645, Free PMC Article
    3. RNA-Seq Analysis of Differential Splice Junction Usage and Intron Retentions by DEXSeq. Li Y, et al. PLoS One, 2015. PMID 26327458, Free PMC Article
    4. ON selectivity in the Drosophila visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition. Molina-Obando S, et al. Elife, 2019 Sep 19. PMID 31535971, Free PMC Article
    5. Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4. Baltzer C, et al. PLoS One, 2009 Sep 9. PMID 19742324, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate synthase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate synthase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ammonia assimilation cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9674-PA
    CG9674-PD
    CG9674-PE
    CG9674-PF
    CG9674-PG
    CG9674-PH
    CG9674-PI
    glutamate synthase
    NP_001246803.1
    NP_001246804.1
    NP_001261973.1
    NP_001261974.1
    NP_001287088.1
    NP_648922.1
    NP_788517.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16787573..16807731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176339.2 → NP_788517.1  uncharacterized protein Dmel_CG9674, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX95, Q9VVA3, Q9VVA4
      Related
      FBpp0075103
      Conserved Domains (8) summary
      PRK11750
      Location:75 → 1564
      gltB; glutamate synthase subunit alpha; Provisional
      PRK12810
      Location:1622 → 2105
      gltD; glutamate synthase subunit beta; Reviewed
      cd00982
      Location:1315 → 1564
      gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
      cd02808
      Location:917 → 1270
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:88 → 504
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:542 → 827
      Glu_syn_central; Glutamate synthase central domain
      pfam13450
      Location:1771 → 1803
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl19102
      Location:1644 → 1755
      Fer4_8; 4Fe-4S dicluster domain

    2. NM_001300159.1 → NP_001287088.1  uncharacterized protein Dmel_CG9674, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287088.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCU8
      Conserved Domains (5) summary
      COG0067
      Location:76 → 456
      GltB1; Glutamate synthase domain 1 [Amino acid transport and metabolism]
      COG0069
      Location:786 → 1164
      GltB2; Glutamate synthase domain 2 [Amino acid transport and metabolism]
      cd02808
      Location:917 → 1164
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:88 → 504
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:542 → 827
      Glu_syn_central; Glutamate synthase central domain

    3. NM_001275044.1 → NP_001261973.1  uncharacterized protein Dmel_CG9674, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFH8
      Conserved Domains (8) summary
      PRK11750
      Location:75 → 1565
      gltB; glutamate synthase subunit alpha; Provisional
      PRK12810
      Location:1623 → 2106
      gltD; glutamate synthase subunit beta; Reviewed
      cd00982
      Location:1316 → 1565
      gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
      cd02808
      Location:918 → 1271
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:88 → 504
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:543 → 828
      Glu_syn_central; Glutamate synthase central domain
      pfam13450
      Location:1772 → 1804
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl19102
      Location:1645 → 1756
      Fer4_8; 4Fe-4S dicluster domain

    4. NM_001259875.2 → NP_001246804.1  uncharacterized protein Dmel_CG9674, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFH8
      Conserved Domains (8) summary
      PRK11750
      Location:75 → 1565
      gltB; glutamate synthase subunit alpha; Provisional
      PRK12810
      Location:1623 → 2106
      gltD; glutamate synthase subunit beta; Reviewed
      cd00982
      Location:1316 → 1565
      gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
      cd02808
      Location:918 → 1271
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:88 → 504
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:543 → 828
      Glu_syn_central; Glutamate synthase central domain
      pfam13450
      Location:1772 → 1804
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl19102
      Location:1645 → 1756
      Fer4_8; 4Fe-4S dicluster domain

    5. NM_140665.2 → NP_648922.1  uncharacterized protein Dmel_CG9674, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648922.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX95, Q9VVA3, Q9VVA4
      Related
      FBpp0075100
      Conserved Domains (8) summary
      PRK11750
      Location:75 → 1564
      gltB; glutamate synthase subunit alpha; Provisional
      PRK12810
      Location:1622 → 2105
      gltD; glutamate synthase subunit beta; Reviewed
      cd00982
      Location:1315 → 1564
      gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
      cd02808
      Location:917 → 1270
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:88 → 504
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:542 → 827
      Glu_syn_central; Glutamate synthase central domain
      pfam13450
      Location:1771 → 1803
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl19102
      Location:1644 → 1755
      Fer4_8; 4Fe-4S dicluster domain

    6. NM_001275045.1 → NP_001261974.1  uncharacterized protein Dmel_CG9674, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCU8
      Conserved Domains (5) summary
      COG0067
      Location:76 → 456
      GltB1; Glutamate synthase domain 1 [Amino acid transport and metabolism]
      COG0069
      Location:786 → 1164
      GltB2; Glutamate synthase domain 2 [Amino acid transport and metabolism]
      cd02808
      Location:917 → 1164
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:88 → 504
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:542 → 827
      Glu_syn_central; Glutamate synthase central domain

    7. NM_001259874.1 → NP_001246803.1  uncharacterized protein Dmel_CG9674, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCU8
      Conserved Domains (5) summary
      COG0067
      Location:76 → 456
      GltB1; Glutamate synthase domain 1 [Amino acid transport and metabolism]
      COG0069
      Location:786 → 1164
      GltB2; Glutamate synthase domain 2 [Amino acid transport and metabolism]
      cd02808
      Location:917 → 1164
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:88 → 504
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:542 → 827
      Glu_syn_central; Glutamate synthase central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NFH8 M9NFH8
    M9PCU8 M9PCU8
    Q86PB9 Q86PB9
    Q9VVA4 Q9VVA4

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