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    Adcy10 adenylate cyclase 10 [ Mus musculus (house mouse) ]

    Gene ID: 271639, updated on 13-Jan-2025

    Summary

    Official Symbol
    Adcy10provided by MGI
    Official Full Name
    adenylate cyclase 10provided by MGI
    Primary source
    MGI:MGI:2660854
    See related
    Ensembl:ENSMUSG00000026567 AllianceGenome:MGI:2660854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sAC; Sacy; 4931412F17; 4930431D04Rik
    Summary
    Predicted to enable several functions, including ATPase binding activity; bicarbonate binding activity; and manganese ion binding activity. Predicted to be involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of apoptotic process; and positive regulation of metabolic process. Located in apical plasma membrane. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human ADCY10 (adenylate cyclase 10). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward testis adult (RPKM 24.0) See more
    Orthologs
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    Genomic context

    See Adcy10 in Genome Data Viewer
    Location:
    1 H2.3; 1 72.83 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165309114..165404347)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165483518..165576778)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E2016 Neighboring gene STARR-positive B cell enhancer ABC_E119 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene peptidylprolyl isomerase A pseudogene 1_1625.1 Neighboring gene zinc finger protein 758 pseudogene Neighboring gene predicted gene, 51751 Neighboring gene predicted gene, 51750 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167509733-167510033 Neighboring gene STARR-positive B cell enhancer ABC_E11103 Neighboring gene myelin protein zero-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E4372 Neighboring gene STARR-positive B cell enhancer ABC_E324 Neighboring gene nuclear encoded tRNA proline 2 (anticodon AGG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATPase binding  
    enables ATPase binding  
    enables adenylate cyclase activity  
    enables adenylate cyclase activity  
    enables adenylate cyclase activity  
    enables adenylate cyclase activity PubMed 
    enables bicarbonate binding  
    enables bicarbonate binding  
    enables magnesium ion binding  
    enables manganese ion binding  
    enables manganese ion binding  
    enables protein binding PubMed 
    Items 1 - 25 of 51
    Process Evidence Code Pubs
    involved_in cAMP biosynthetic process  
    involved_in cAMP biosynthetic process  
    involved_in epithelial cilium movement involved in extracellular fluid movement  
    involved_in epithelial cilium movement involved in extracellular fluid movement  
    involved_in glucose catabolic process  
    involved_in glucose catabolic process  
    involved_in intracellular signal transduction  
    involved_in mitochondrial ATP transmembrane transport  
    involved_in mitochondrial ATP transmembrane transport  
    involved_in negative regulation of cardiac muscle cell contraction  
    involved_in negative regulation of cardiac muscle cell contraction  
    involved_in negative regulation of mitochondrial membrane potential  
    involved_in negative regulation of mitochondrial membrane potential  
    involved_in negative regulation of reactive oxygen species biosynthetic process  
    involved_in negative regulation of reactive oxygen species biosynthetic process  
    involved_in neuron projection extension  
    involved_in neuron projection extension  
    involved_in neuron projection maintenance  
    involved_in neuron projection maintenance  
    involved_in neuron projection retraction  
    involved_in neuron projection retraction  
    involved_in positive regulation of ATP biosynthetic process  
    involved_in positive regulation of ATP biosynthetic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of axon extension  
    involved_in positive regulation of axon extension  
    involved_in positive regulation of cardiac muscle cell apoptotic process  
    involved_in positive regulation of cardiac muscle cell apoptotic process  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of glycogen catabolic process  
    involved_in positive regulation of glycogen catabolic process  
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of mitochondrial depolarization  
    involved_in positive regulation of mitochondrial depolarization  
    involved_in positive regulation of ossification  
    involved_in positive regulation of ossification  
    involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in positive regulation of peptidyl-threonine phosphorylation  
    involved_in positive regulation of protein targeting to mitochondrion  
    involved_in positive regulation of protein targeting to mitochondrion  
    involved_in positive regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process  
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process  
    involved_in regulation of membrane repolarization  
    involved_in regulation of membrane repolarization  
    involved_in regulation of mitophagy  
    involved_in regulation of mitophagy  
    involved_in spermatid development  
    Items 1 - 25 of 51
    Items 1 - 20 of 31
    Component Evidence Code Pubs
    located_in apical part of cell  
    located_in apical plasma membrane PubMed 
    located_in astrocyte end-foot  
    located_in astrocyte end-foot  
    located_in axon  
    located_in basal part of cell  
    located_in basal part of cell  
    located_in central region of growth cone  
    located_in central region of growth cone  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    located_in dendrite  
    located_in extracellular region  
    located_in growth cone  
    located_in membrane PubMed 
    colocalizes_with microtubule cytoskeleton  
    colocalizes_with microtubule cytoskeleton  
    located_in mitochondrion  
    located_in mitochondrion  
    colocalizes_with motile cilium  
    colocalizes_with motile cilium  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    Items 1 - 20 of 31

    General protein information

    Preferred Names
    adenylate cyclase type 10
    Names
    germ cell soluble adenylyl cyclase
    testicular soluble adenylyl cyclase
    NP_001344356.1
    NP_766617.2
    XP_006496930.1
    XP_011237125.1
    XP_017176545.1
    XP_017176549.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357427.1NP_001344356.1  adenylate cyclase type 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102776, AC162789
    2. NM_173029.3NP_766617.2  adenylate cyclase type 10 isoform 1

      See identical proteins and their annotated locations for NP_766617.2

      Status: VALIDATED

      Source sequence(s)
      AK029849, BC138448
      Consensus CDS
      CCDS35756.1
      UniProtKB/Swiss-Prot
      B2RRJ9, Q3V0F8, Q8C0T9
      Related
      ENSMUSP00000027852.9, ENSMUST00000027852.15
      Conserved Domains (2) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG3899
      Location:485959
      COG3899; Predicted ATPase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165309114..165404347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321056.3XP_017176545.1  adenylate cyclase type 10 isoform X1

      UniProtKB/Swiss-Prot
      B2RRJ9, Q3V0F8, Q8C0T9
      Conserved Domains (2) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG3899
      Location:485959
      COG3899; Predicted ATPase [General function prediction only]
    2. XM_017321060.2XP_017176549.1  adenylate cyclase type 10 isoform X2

      UniProtKB/TrEMBL
      E9Q9T4
      Related
      ENSMUSP00000107066.2, ENSMUST00000111439.8
      Conserved Domains (2) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG3899
      Location:485959
      COG3899; Predicted ATPase [General function prediction only]
    3. XM_006496867.1XP_006496930.1  adenylate cyclase type 10 isoform X1

      See identical proteins and their annotated locations for XP_006496930.1

      UniProtKB/Swiss-Prot
      B2RRJ9, Q3V0F8, Q8C0T9
      Conserved Domains (2) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG3899
      Location:485959
      COG3899; Predicted ATPase [General function prediction only]
    4. XM_011238823.3XP_011237125.1  adenylate cyclase type 10 isoform X3

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