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    Ggt1 gamma-glutamyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14598, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ggt1provided by MGI
    Official Full Name
    gamma-glutamyltransferase 1provided by MGI
    Primary source
    MGI:MGI:95706
    See related
    Ensembl:ENSMUSG00000006345 AllianceGenome:MGI:95706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GGT; dwg; Ggtp; CD224; GGT 1; GGT-1
    Summary
    This gene encodes gamma-glutamyl transpeptidase, a plasmamembrane-associated enzyme that cleaves the peptide bond between gamma-glutamyl and cysteinyl glycine moieties of glutathione. The encoded protein is autocatalytically processed to generate an enzymatically active heterodimer comprised of heavy and light chains. Mice lacking the encoded protein grow slowly, develop cataracts and have elevated levels of glutathione in plasma and urine. Transgenic overexpression of the encoded protein in mice enhances osteoclastic bone resorption. The mutant alleles termed 'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with deletions in this gene. A gamma-glutamyl transpeptidase paralog is located adjacent to this gene. Alternative splicing results in multiple transcript variants. Additional transcripts using alternate promoters and differing in 5' UTRs have been described. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in kidney adult (RPKM 265.8), duodenum adult (RPKM 234.7) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ggt1 in Genome Data Viewer
    Location:
    10 C1; 10 38.55 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75396910..75422027)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75561076..75586193)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein D3 Neighboring gene predicted gene, 35061 Neighboring gene leucine rich repeat containing 75B Neighboring gene STARR-positive B cell enhancer ABC_E5147 Neighboring gene gamma-glutamyltransferase 5 Neighboring gene predicted gene, 26402 Neighboring gene predicted gene, 19688

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (2 hits/79 screens)

    Associated conditions

    Description Tests
    dwarf grey
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminoacyltransferase activity  
    enables glutathione hydrolase activity  
    enables glutathione hydrolase activity  
    enables glutathione hydrolase activity PubMed 
    enables leukotriene C4 gamma-glutamyl transferase activity  
    enables leukotriene-C(4) hydrolase  
    enables leukotriene-C(4) hydrolase  
    enables peptidyltransferase activity  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress  
    involved_in cysteine biosynthetic process PubMed 
    involved_in glutamate metabolic process  
    involved_in glutathione biosynthetic process PubMed 
    involved_in glutathione catabolic process  
    involved_in glutathione catabolic process  
    acts_upstream_of_or_within glutathione metabolic process PubMed 
    involved_in hepatoblast differentiation  
    involved_in hepatocyte differentiation  
    involved_in liver regeneration  
    involved_in peptide modification  
    involved_in peptide modification  
    involved_in peptide modification  
    involved_in regulation of immune system process  
    involved_in regulation of immune system process PubMed 
    involved_in regulation of inflammatory response  
    involved_in regulation of inflammatory response PubMed 
    involved_in response to alcohol  
    involved_in response to estradiol  
    involved_in response to lipopolysaccharide  
    involved_in response to tumor necrosis factor  
    acts_upstream_of_or_within spermatogenesis PubMed 
    involved_in zymogen activation  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    located_in extracellular space  
    located_in extracellular space  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in vesicle PubMed 

    General protein information

    Preferred Names
    glutathione hydrolase 1 proenzyme
    Names
    gamma-glutamyltranspeptidase 1
    leukotriene-C4 hydrolase
    NP_001292921.1
    NP_001366466.1
    NP_001366467.1
    NP_001366468.1
    NP_001366469.1
    NP_001366470.1
    NP_032142.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305992.2NP_001292921.1  glutathione hydrolase 1 proenzyme precursor

      See identical proteins and their annotated locations for NP_001292921.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. All ten variants encode the same protein.
      Source sequence(s)
      AC087540
      Consensus CDS
      CCDS23927.1
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
      Related
      ENSMUSP00000121312.2, ENSMUST00000134503.8
      Conserved Domains (1) summary
      pfam01019
      Location:55563
      G_glu_transpept; Gamma-glutamyltranspeptidase
    2. NM_001379537.1NP_001366466.1  glutathione hydrolase 1 proenzyme precursor

      Status: REVIEWED

      Source sequence(s)
      AC087540
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
      Conserved Domains (1) summary
      pfam01019
      Location:55563
      G_glu_transpept; Gamma-glutamyltranspeptidase
    3. NM_001379538.1NP_001366467.1  glutathione hydrolase 1 proenzyme precursor

      Status: REVIEWED

      Source sequence(s)
      AC087540
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
      Conserved Domains (1) summary
      pfam01019
      Location:55563
      G_glu_transpept; Gamma-glutamyltranspeptidase
    4. NM_001379539.1NP_001366468.1  glutathione hydrolase 1 proenzyme precursor

      Status: REVIEWED

      Source sequence(s)
      AC087540
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
      Conserved Domains (1) summary
      pfam01019
      Location:55563
      G_glu_transpept; Gamma-glutamyltranspeptidase
    5. NM_001379540.1NP_001366469.1  glutathione hydrolase 1 proenzyme precursor

      Status: REVIEWED

      Source sequence(s)
      AC087540
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
      Conserved Domains (1) summary
      pfam01019
      Location:55563
      G_glu_transpept; Gamma-glutamyltranspeptidase
    6. NM_001379541.1NP_001366470.1  glutathione hydrolase 1 proenzyme precursor

      Status: REVIEWED

      Source sequence(s)
      AC087540
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
      Conserved Domains (1) summary
      pfam01019
      Location:55563
      G_glu_transpept; Gamma-glutamyltranspeptidase
    7. NM_001428490.1NP_001415419.1  glutathione hydrolase 1 proenzyme precursor

      Status: REVIEWED

      Source sequence(s)
      AC087540
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
    8. NM_001428491.1NP_001415420.1  glutathione hydrolase 1 proenzyme precursor

      Status: REVIEWED

      Source sequence(s)
      AC087540
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
    9. NM_001428492.1NP_001415421.1  glutathione hydrolase 1 proenzyme precursor

      Status: REVIEWED

      Source sequence(s)
      AC087540
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
    10. NM_008116.4NP_032142.1  glutathione hydrolase 1 proenzyme precursor

      See identical proteins and their annotated locations for NP_032142.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. All ten variants encode the same protein.
      Source sequence(s)
      AC087540
      Consensus CDS
      CCDS23927.1
      UniProtKB/Swiss-Prot
      Q60928
      UniProtKB/TrEMBL
      Q4FK56
      Related
      ENSMUSP00000006508.4, ENSMUST00000006508.10
      Conserved Domains (1) summary
      pfam01019
      Location:55563
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75396910..75422027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003948592.1 RNA Sequence

    2. XR_003948591.1 RNA Sequence

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