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    IL22RA1 interleukin 22 receptor subunit alpha 1 [ Homo sapiens (human) ]

    Gene ID: 58985, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IL22RA1provided by HGNC
    Official Full Name
    interleukin 22 receptor subunit alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:13700
    See related
    Ensembl:ENSG00000142677 MIM:605457; AllianceGenome:HGNC:13700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL22R; CRF2-9; IL22R1
    Summary
    The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in pancreas (RPKM 15.5), skin (RPKM 14.3) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL22RA1 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (24119771..24143140, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23957480..23980846, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24446261..24469630, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene myomesin 3 Neighboring gene uncharacterized LOC124903878 Neighboring gene uncharacterized LOC105376864 Neighboring gene Sharpr-MPRA regulatory region 3135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24433598-24434138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24438827-24439335 Neighboring gene Sharpr-MPRA regulatory region 13639 Neighboring gene uncharacterized LOC124903879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24479387-24479984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24479985-24480582 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:24480583-24481180 Neighboring gene interferon lambda receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 391 Neighboring gene long intergenic non-protein coding RNA 2800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Change of IL-22R1 expression in human airway smooth muscle cells in response to different stimulating agents]. Zhang Z, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2011 Jun. PMID 21690049
    2. Interleukin-22 receptor is overexpressed in nonsmall cell lung cancer and portends a poor prognosis. Guillon A, et al. Eur Respir J, 2016 Apr. PMID 26846835
    3. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Tohyama M, et al. Eur J Immunol, 2009 Oct. PMID 19731362
    4. Interleukin 22 receptor 1 expression in pancreas islets. Shioya M, et al. Pancreas, 2008 Mar. PMID 18376313
    5. IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1. Hebert KD, et al. Respir Res, 2019 Aug 15. PMID 31416461, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis.
      Title: Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis.
    2. Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
      Title: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
    3. Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
      Title: Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
    4. Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
      Title: Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
    5. Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection.
      Title: Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection.
    6. Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
      Title: Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
    7. Increased expression of interleukin-22 and its receptor is relevant to poor prognosis in laryngeal squamous cell carcinoma: A case control trial.
      Title: Increased expression of interleukin-22 and its receptor is relevant to poor prognosis in laryngeal squamous cell carcinoma: A case control trial.
    8. Targeting IL-22 and IL-22R protects against experimental osteoarthritis.
      Title: Targeting IL-22 and IL-22R protects against experimental osteoarthritis.
    9. High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer.
      Title: High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer.
    10. Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis.
      Title: Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of interleukin 22 receptor, alpha 1 (IL22RA1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interferon receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables interleukin-20 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-22 receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-22-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-22 receptor subunit alpha-1
    Names
    IL-22 receptor subunit alpha-1
    IL-22R-alpha-1
    IL-22RA1
    cytokine receptor class-II member 9
    cytokine receptor family 2 member 9
    interleukin 22 receptor, alpha 1
    zcytoR11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021258.4 → NP_067081.2  interleukin-22 receptor subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_067081.2

      Status: REVIEWED

      Source sequence(s)
      AK313971, BC029273
      Consensus CDS
      CCDS247.1
      UniProtKB/Swiss-Prot
      A8K839, B2R9Y9, Q8N6P7, Q9HB22
      UniProtKB/TrEMBL
      B4E2V9
      Related
      ENSP00000270800.1, ENST00000270800.2
      Conserved Domains (3) summary
      PHA03247
      Location:305 → 529
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:293 → 401
      PRK10263; DNA translocase FtsK; Provisional
      pfam01108
      Location:4 → 107
      Tissue_fac; Tissue factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      24119771..24143140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23957480..23980846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6P7.1 GenPept UniProtKB/Swiss-Prot:Q8N6P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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