Sh3yl1 Sh3 domain YSC-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sh3yl1provided by MGI
Official Full Name: Sh3 domain YSC-like 1provided by MGI
Primary source: MGI:MGI:1346118
See related: Ensembl:ENSMUSG00000020669 AllianceGenome:MGI:1346118
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ray; YSC84
Summary: Predicted to enable phosphatase binding activity and phosphatidylinositol binding activity. Acts upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Predicted to be active in ruffle membrane. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 10.0), liver E14.5 (RPKM 8.4) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 13.01 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (30961622..31010159)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (30911669..30960160)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1.
Title: LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1.
SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus.
Title: SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

AI314953 (e-PCR)
- UniSTS:180381

D85926 (e-PCR)
- UniSTS:180385

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphatidylinositol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ruffle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SH3 domain-containing YSC84-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289480.1 → NP_001276409.1 SH3 domain-containing YSC84-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_001276409.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.

Source sequence(s)

AC160932, BB433755, BC058557, BY086053

Consensus CDS

CCDS79110.1

UniProtKB/Swiss-Prot

O08641

Related

ENSMUSP00000106504.3, ENSMUST00000110880.3

Conserved Domains (2) summary

cd11525
Location:11 → 171

SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins

cd11841
Location:247 → 300

SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein
NM_013709.5 → NP_038737.1 SH3 domain-containing YSC84-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_038737.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AK141199, AV375458

Consensus CDS

CCDS25859.1

UniProtKB/Swiss-Prot

O08641, Q6P7V3, Q6PDR3

Related

ENSMUSP00000020997.9, ENSMUST00000020997.15

Conserved Domains (2) summary

cd11525
Location:11 → 209

SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins

cd11841
Location:285 → 338

SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

RNA

NR_110343.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.

Source sequence(s)

AC160932
NR_186254.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC160932