Krt86 keratin 86 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt86provided by MGI
Official Full Name: keratin 86provided by MGI
Primary source: MGI:MGI:109362
See related: Ensembl:ENSMUSG00000067614 AllianceGenome:MGI:109362
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Khb4; MHb4; Krt2-10; Krt2-11; 5430421N21Rik
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Is expressed in digit epidermis and hair shaft. Human ortholog(s) of this gene implicated in hair disease and monilethrix. Orthologous to human KRT86 (keratin 86). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 15 F2; 15 56.9 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101371359..101377864)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101473478..101479983)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type II cuticular Hb6

Names: K86; keratin complex 2, basic, gene 10; type II hair keratin Hb6; type-II keratin Kb26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010667.2 → NP_034797.1 keratin, type II cuticular Hb6

See identical proteins and their annotated locations for NP_034797.1

Status: PROVISIONAL

Source sequence(s)

AK161149

Consensus CDS

CCDS37218.1

UniProtKB/Swiss-Prot

P97861, Q3TTV9

UniProtKB/TrEMBL

B2RTB6, Q61726

Related

ENSMUSP00000085365.4, ENSMUST00000088049.5

Conserved Domains (3) summary

pfam00038
Location:105 → 416

Filament; Intermediate filament protein

pfam16208
Location:4 → 102

Keratin_2_head; Keratin type II head

cl23720
Location:315 → 383

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)