Yars1 tyrosyl-tRNA synthetase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Yars1provided by MGI
Official Full Name: tyrosyl-tRNA synthetase 1provided by MGI
Primary source: MGI:MGI:2147627
See related: Ensembl:ENSMUSG00000028811 AllianceGenome:MGI:2147627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Yars
Summary: Predicted to enable small molecule binding activity and tyrosine-tRNA ligase activity. Predicted to be involved in response to starvation and tyrosyl-tRNA aminoacylation. Predicted to be located in nuclear body. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Charcot-Marie-Tooth disease dominant intermediate C. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 20.4), cerebellum adult (RPKM 19.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 63.05 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (129083595..129113033)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (129189734..129219240)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

conclusion is further supported by a positive correlation across brain regions between TyrRS expression and arginine-accelerated KTP production.
Title: Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in mammals.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126127 (e-PCR)
- UniSTS:162839

NoName (e-PCR)
- UniSTS:235040

RH136524 (e-PCR)
- UniSTS:210506

Yars (e-PCR), detects polymorphism
- UniSTS:507330

RH125457 (e-PCR)
- UniSTS:162276

RH126097 (e-PCR)
- UniSTS:162809

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tyrosine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tyrosine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables tyrosine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in response to starvation	IEA Inferred from Electronic Annotation more info
involved_in response to starvation	ISO Inferred from Sequence Orthology more info
involved_in tyrosyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tyrosyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tyrosine--tRNA ligase, cytoplasmic

Names: tyrRS; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic

NP_598912.5

EC 6.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134151.5 → NP_598912.5 tyrosine--tRNA ligase, cytoplasmic

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AL606977

Consensus CDS

CCDS18685.2

UniProtKB/Swiss-Prot

Q3TEC8, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183, Q91WQ3

UniProtKB/TrEMBL

A2A7S7

Related

ENSMUSP00000101669.4, ENSMUST00000106054.4

Conserved Domains (2) summary

PLN02610
Location:327 → 528

PLN02610; probable methionyl-tRNA synthetase

cl00015
Location:8 → 328

nt_trans; nucleotidyl transferase superfamily