Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmc3provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, ATPase 3provided by MGI
Primary source: MGI:MGI:1098754
See related: Ensembl:ENSMUSG00000002102 AllianceGenome:MGI:1098754
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TBP-1
Summary: Predicted to enable identical protein binding activity and proteasome-activating activity. Acts upstream of or within blastocyst development. Located in P-body. Part of proteasome accessory complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 179.9), CNS E11.5 (RPKM 103.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 50.44 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (90884361..90889783)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (91054016..91059438)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production.
Title: PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126539 (e-PCR)
- UniSTS:209675

Psmc3 (e-PCR), detects polymorphism
- UniSTS:507182

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome regulatory subunit 6A

Names: 26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; TAT-binding protein 1; Tat binding protein 1; proteasome 26S subunit ATPase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008948.2 → NP_032974.2 26S proteasome regulatory subunit 6A

See identical proteins and their annotated locations for NP_032974.2

Status: VALIDATED

Source sequence(s)

AK167002, BE989849, CX201527

Consensus CDS

CCDS16423.1

UniProtKB/Swiss-Prot

O88685, Q99JN8

UniProtKB/TrEMBL

Q3TKC2

Related

ENSMUSP00000071054.8, ENSMUST00000067663.14

Conserved Domains (1) summary

COG1222
Location:28 → 435

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]