Pabpn1l poly(A)binding protein nuclear 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pabpn1lprovided by MGI
Official Full Name: poly(A)binding protein nuclear 1-likeprovided by MGI
Primary source: MGI:MGI:2685954
See related: Ensembl:ENSMUSG00000069867 AllianceGenome:MGI:2685954
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1108; ePABP2; Pabpnl1
Summary: Enables poly(A) binding activity. Acts upstream of or within maternal-to-zygotic transition of gene expression and negative regulation of macromolecule metabolic process. Located in cytoplasm. Is expressed in 1-cell stage embryo; gonad; retina; and thymus. Orthologous to human PABPN1L (PABPN1 like, cytoplasmic). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in ovary adult (RPKM 1.6), thymus adult (RPKM 0.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 71.93 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123346210..123349474, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (122619471..122622735, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PABPN1L is required for maternal mRNA degradation after meiosis resumption.
Title: PABPN1L is required for maternal mRNA degradation after meiosis resumption.
PABPN1L assemble into ""ring-like"" aggregates in the cytoplasm of MII oocytes and is associated with female infertilitydagger.
Title: PABPN1L assemble into "ring-like" aggregates in the cytoplasm of MII oocytes and is associated with female infertility†.
PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition.
Title: PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1)

General gene information

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Markers

Pabpnl1 (e-PCR), detects polymorphism
- UniSTS:496559

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(A) binding	ISA Inferred from Sequence Alignment more info	PubMed
enables poly(A) binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within maternal-to-zygotic transition of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISA Inferred from Sequence Alignment more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: embryonic polyadenylate-binding protein 2

Names: T-cell receptor alpha chain V region (8/10-2); ePABP-2; embryonic poly(A) binding protein 2; embryonic poly(A)-binding protein type II; poly(A)-binding protein nuclear-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007462.1 → NP_001007463.1 embryonic polyadenylate-binding protein 2

See identical proteins and their annotated locations for NP_001007463.1

Status: PROVISIONAL

Source sequence(s)

BK001615

Consensus CDS

CCDS22743.1

UniProtKB/Swiss-Prot

B9EJ43, Q5XFR0

UniProtKB/TrEMBL

B7ZP52

Related

ENSMUSP00000090747.3, ENSMUST00000093059.3

Conserved Domains (2) summary

COG0724
Location:134 → 227

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cl17169
Location:144 → 220

RRM_SF; RNA recognition motif (RRM) superfamily