Birc6 baculoviral IAP repeat-containing 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Birc6provided by MGI
Official Full Name: baculoviral IAP repeat-containing 6provided by MGI
Primary source: MGI:MGI:1276108
See related: Ensembl:ENSMUSG00000024073 AllianceGenome:MGI:1276108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bruce; mKIAA1289; A430032G04Rik; A430040A19Rik; D630005A10Rik
Summary: Enables ubiquitin conjugating enzyme activity. Involved in placenta development. Acts upstream of or within embryonic placenta development; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human BIRC6 (baculoviral IAP repeat containing 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 13.8), spleen adult (RPKM 8.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E2; 17 45.64 cM

Exon count:: 75

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (74835247..75010351)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (74528254..74703356)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer's disease.
Title: BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer's disease.
BRUCE preserves genomic stability in the male germline of mice.
Title: BRUCE preserves genomic stability in the male germline of mice.
Data indicate BRUCE/Apollon/Birc6, an inhibitor of apoptosis protein (IAP), as a new autophagy regulator.
Title: The IAP family member BRUCE regulates autophagosome-lysosome fusion.
Humanin signaling pathway via htHNR/JAKs/STAT3 increased the expression levels of mRNA and protein of Apollon/Bruce, an unusual member of the inhibitors of apoptosis proteins
Title: Apollon/Bruce is upregulated by Humanin.
BRUCE acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8) and BRIT1 in a complex to coordinate USP8-catalyzed deubiquitination of BRIT1.
Title: BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.
These results establish a previously unrecognized link between NFAT signaling and regulation of IAP expression and are the first to identify a signaling pathway that increases BRUCE expression.
Title: Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE.
review of role of Apollonin in mechanisms of apoptosis and cell division
Title: An Apollon vista of death and destruction.
p53 is a downstream effector of Bruce, and, in response to loss of Bruce function, p53 activates Pidd/caspase-2 and Bax/Bak, leading to mitochondrial apoptosis
Title: The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.
BRUCE protects cells against apoptosis and functions as an inhibitor of apoptosis.
Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.
Birc6 plays a role in cell division
Title: Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Gene trapped (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237695

NoName (e-PCR)
- UniSTS:237696

NoName (e-PCR)
- UniSTS:224248

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein ubiquitination	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spongiotrophoblast layer development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6; baculoviral IAP repeat-containing protein 6

Names: BIR repeat-containing ubiquitin-conjugating enzyme; RING-type E3 ubiquitin transferase BIRC6; apollon; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6; ubiquitin-conjugating BIR domain enzyme apollon

NP_001389698.1

EC 2.3.2.24

NP_031592.3

EC 2.3.2.24

XP_006523581.1

EC 2.3.2.24

XP_006523582.1

EC 2.3.2.24

XP_006523583.1

EC 2.3.2.24

XP_006523584.1

EC 2.3.2.24

XP_006523585.1

EC 2.3.2.24

XP_006523587.1

EC 2.3.2.24

XP_006523589.1

EC 2.3.2.24

XP_006523590.1

EC 2.3.2.24

XP_006523591.1

EC 2.3.2.24

XP_011244559.1

EC 2.3.2.24

XP_030105313.1

EC 2.3.2.24

XP_030105314.1

EC 2.3.2.24

XP_030105315.1

EC 2.3.2.24

XP_030105316.1

EC 2.3.2.24

XP_030105317.1

EC 2.3.2.24

XP_030105318.1

EC 2.3.2.24

XP_036016165.1

EC 2.3.2.24

XP_036016166.1

EC 2.3.2.24

XP_036016167.1

EC 2.3.2.24

XP_036016168.1

EC 2.3.2.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402769.1 → NP_001389698.1 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 2

Status: VALIDATED

Source sequence(s)

AC098726, AC154442

UniProtKB/Swiss-Prot

E9PYU6, O88738, Q69ZM5, Q8BNX0, Q8BR72, Q8BRV7, Q8C737

UniProtKB/TrEMBL

A0A1S6GWH3, S4R2P8

Related

ENSMUSP00000138333.2, ENSMUST00000182597.8
NM_007566.3 → NP_031592.3 dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 1

Status: VALIDATED

Source sequence(s)

AC098726, AC154442, AK041241, AK042247, AK045446, AK052612, AK134254, AK173143, BG695066, CN536181, CN707067, CO424370, DV651019

Consensus CDS

CCDS37693.2

UniProtKB/TrEMBL

S4R2P8

Related

ENSMUSP00000136329.2, ENSMUST00000180037.8

Conserved Domains (3) summary

cd00022
Location:290 → 363

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4613 → 4751

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3480 → 3632

DUF3643; Protein of unknown function (DUF3643)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

74835247..75010351

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523518.3 → XP_006523581.1 baculoviral IAP repeat-containing protein 6 isoform X1

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4693 → 4831

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3558 → 3712

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_006523520.4 → XP_006523583.1 baculoviral IAP repeat-containing protein 6 isoform X3

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4687 → 4825

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3552 → 3706

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_006523522.4 → XP_006523585.1 baculoviral IAP repeat-containing protein 6 isoform X5

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4684 → 4822

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3549 → 3703

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_006523524.4 → XP_006523587.1 baculoviral IAP repeat-containing protein 6 isoform X9

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4678 → 4816

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3543 → 3697

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_006523521.4 → XP_006523584.1 baculoviral IAP repeat-containing protein 6 isoform X4

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4687 → 4825

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3552 → 3706

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_030249454.2 → XP_030105314.1 baculoviral IAP repeat-containing protein 6 isoform X10

UniProtKB/TrEMBL

A0A1S6GWH6

Related

ENSMUSP00000138270.2, ENSMUST00000183224.8

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4678 → 4816

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3543 → 3697

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_006523527.4 → XP_006523590.1 baculoviral IAP repeat-containing protein 6 isoform X14

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4660 → 4798

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3525 → 3679

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_006523519.4 → XP_006523582.1 baculoviral IAP repeat-containing protein 6 isoform X2

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4689 → 4827

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3554 → 3708

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_036160272.1 → XP_036016165.1 baculoviral IAP repeat-containing protein 6 isoform X6

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4683 → 4821

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3548 → 3702

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_030249453.2 → XP_030105313.1 baculoviral IAP repeat-containing protein 6 isoform X7

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4680 → 4818

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3545 → 3699

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_030249456.2 → XP_030105316.1 baculoviral IAP repeat-containing protein 6 isoform X16

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4656 → 4794

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3521 → 3675

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_036160273.1 → XP_036016166.1 baculoviral IAP repeat-containing protein 6 isoform X12

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4673 → 4811

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3538 → 3692

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_030249457.2 → XP_030105317.1 baculoviral IAP repeat-containing protein 6 isoform X18

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4646 → 4784

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3511 → 3665

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_030249455.2 → XP_030105315.1 baculoviral IAP repeat-containing protein 6 isoform X11

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4675 → 4813

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3540 → 3694

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_006523526.5 → XP_006523589.1 baculoviral IAP repeat-containing protein 6 isoform X13

UniProtKB/TrEMBL

A0A1S6GWH6

Related

ENSMUSP00000138732.2, ENSMUST00000182944.8

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4666 → 4804

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3531 → 3685

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_036160274.1 → XP_036016167.1 baculoviral IAP repeat-containing protein 6 isoform X15

UniProtKB/TrEMBL

A0A1S6GWH6

Related

ENSMUSP00000138693.2, ENSMUST00000182133.8

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4660 → 4798

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3525 → 3679

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_030249458.2 → XP_030105318.1 baculoviral IAP repeat-containing protein 6 isoform X19

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4642 → 4780

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3507 → 3661

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_006523528.5 → XP_006523591.1 baculoviral IAP repeat-containing protein 6 isoform X17

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4649 → 4787

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3514 → 3668

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_036160275.1 → XP_036016168.1 baculoviral IAP repeat-containing protein 6 isoform X20

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (3) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd00195
Location:4630 → 4768

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

pfam12356
Location:3495 → 3649

BIRC6; Baculoviral IAP repeat-containing protein 6
XM_011246257.4 → XP_011244559.1 baculoviral IAP repeat-containing protein 6 isoform X21

UniProtKB/TrEMBL

A0A1S6GWH6

Conserved Domains (2) summary

cd00022
Location:347 → 420

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

pfam12356
Location:3558 → 3712

BIRC6; Baculoviral IAP repeat-containing protein 6