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    Pnrc2 proline-rich nuclear receptor coactivator 2 [ Mus musculus (house mouse) ]

    Gene ID: 52830, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pnrc2provided by MGI
    Official Full Name
    proline-rich nuclear receptor coactivator 2provided by MGI
    Primary source
    MGI:MGI:106512
    See related
    Ensembl:ENSMUSG00000028675 AllianceGenome:MGI:106512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4Bwg0593e; 0610011E17Rik
    Summary
    Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in P-body and nucleus. Is expressed in several structures, including brain ventricular layer; genitourinary system; retina; and thymus primordium. Orthologous to human PNRC2 (proline rich nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 35.1), placenta adult (RPKM 28.9) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pnrc2 in Genome Data Viewer
    Location:
    4 D3; 4 68.01 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135598229..135601157, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135870917..135873846, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene myomesin family, member 3 Neighboring gene STARR-seq mESC enhancer starr_11736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135411492-135411675 Neighboring gene STARR-positive B cell enhancer ABC_E7999 Neighboring gene serine and arginine-rich splicing factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E4683 Neighboring gene STARR-positive B cell enhancer ABC_E1660 Neighboring gene STARR-seq mESC enhancer starr_11738 Neighboring gene STARR-positive B cell enhancer ABC_E8000 Neighboring gene STARR-positive B cell enhancer ABC_E4684 Neighboring gene STARR-seq mESC enhancer starr_11739 Neighboring gene cannabinoid receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E4685 Neighboring gene fucosidase, alpha-L- 1, tissue

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC11707

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    is_active_in P-body  
    located_in P-body  
    located_in P-body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    proline-rich nuclear receptor coactivator 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026383.3NP_080659.1  proline-rich nuclear receptor coactivator 2

      See identical proteins and their annotated locations for NP_080659.1

      Status: VALIDATED

      Source sequence(s)
      AK011192, AK012073, AL672076
      Consensus CDS
      CCDS18792.1
      UniProtKB/Swiss-Prot
      B1AV48, B1AV49, Q9CR73, Q9CXC6
      Related
      ENSMUSP00000030436.6, ENSMUST00000030436.12
      Conserved Domains (1) summary
      pfam15365
      Location:94112
      PNRC; Proline-rich nuclear receptor coactivator motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135598229..135601157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539038.2XP_006539101.1  proline-rich nuclear receptor coactivator 2 isoform X1

      See identical proteins and their annotated locations for XP_006539101.1

      UniProtKB/Swiss-Prot
      B1AV48, B1AV49, Q9CR73, Q9CXC6
      Conserved Domains (1) summary
      pfam15365
      Location:94112
      PNRC; Proline-rich nuclear receptor coactivator motif
    2. XM_006539039.2XP_006539102.1  proline-rich nuclear receptor coactivator 2 isoform X1

      See identical proteins and their annotated locations for XP_006539102.1

      UniProtKB/Swiss-Prot
      B1AV48, B1AV49, Q9CR73, Q9CXC6
      Conserved Domains (1) summary
      pfam15365
      Location:94112
      PNRC; Proline-rich nuclear receptor coactivator motif
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