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    Gpr61 G protein-coupled receptor 61 [ Mus musculus (house mouse) ]

    Gene ID: 229714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr61provided by MGI
    Official Full Name
    G protein-coupled receptor 61provided by MGI
    Primary source
    MGI:MGI:2441719
    See related
    Ensembl:ENSMUSG00000046793 AllianceGenome:MGI:2441719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable G protein-coupled receptor activity and arrestin family protein binding activity. Predicted to be involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be part of receptor complex. Predicted to be active in endosome and plasma membrane. Orthologous to human GPR61 (G protein-coupled receptor 61). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.4), cortex adult (RPKM 2.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr61 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108055660..108062218, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108148321..108154932, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12500 Neighboring gene G protein subunit alpha transducin 2 Neighboring gene G protein subunit alpha i3 Neighboring gene STARR-positive B cell enhancer ABC_E2092 Neighboring gene STARR-positive B cell enhancer ABC_E2093 Neighboring gene predicted gene, 40122 Neighboring gene adhesion molecule with Ig like domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor. Nambu H, et al. Life Sci, 2011 Nov 21. PMID 21971119
    2. Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Xu W, et al. Int J Mol Sci, 2022 May 20. PMID 35628521, Free PMC Article
    3. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that GPR61 is involved in the regulation of food intake and body weight
      Title: Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arrestin family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305461.2 → NP_001292390.1  G-protein coupled receptor 61

      See identical proteins and their annotated locations for NP_001292390.1

      Status: VALIDATED

      Source sequence(s)
      AL671854
      Consensus CDS
      CCDS17752.1
      UniProtKB/Swiss-Prot
      Q3UZR6, Q8C010
      Related
      ENSMUSP00000111988.2, ENSMUST00000116284.2
      Conserved Domains (1) summary
      cd15220
      Location:44 → 352
      7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001411298.1 → NP_001398227.1  G-protein coupled receptor 61

      Status: VALIDATED

      Source sequence(s)
      AL671854
      UniProtKB/Swiss-Prot
      Q3UZR6, Q8C010
      Related
      ENSMUSP00000055557.2, ENSMUST00000062028.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      108055660..108062218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175470.4: Suppressed sequence

      Description
      NM_175470.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C010.2 GenPept UniProtKB/Swiss-Prot:Q8C010

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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