Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aboprovided by MGI
Official Full Name: ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferaseprovided by MGI
Primary source: MGI:MGI:2135738
See related: Ensembl:ENSMUSG00000015787 AllianceGenome:MGI:2135738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NAGAT
Summary: Enables fucosylgalactoside 3-alpha-galactosyltransferase activity and glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus; extracellular region; and vesicle. Is expressed in alimentary system; male reproductive gland or organ; and spleen. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 4.6), colon adult (RPKM 3.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.06 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (26732508..26754973, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (26842496..26864995, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The alphaGal epitope expressed by this transfected enzyme in pancreatic cancer cells delays tumor development after transplantation of nude mice.
Title: Decrease of human pancreatic cancer cell tumorigenicity by alpha1,3galactosyltransferase gene transfer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-1,3-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables antigen binding	ISO Inferred from Sequence Orthology more info
enables fucosylgalactoside 3-alpha-galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histo-blood group ABO system transferase

Names: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase); cis-AB transferase; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; histo-blood group A transferase; histo-blood group B transferase

NP_001277373.1

EC 2.4.1.37

EC 2.4.1.40

NP_109643.3

EC 2.4.1.37

EC 2.4.1.40

XP_006498519.1

EC 2.4.1.37

EC 2.4.1.40

XP_006498521.1

EC 2.4.1.37

EC 2.4.1.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290444.2 → NP_001277373.1 histo-blood group ABO system transferase isoform b

Status: VALIDATED

Source sequence(s)

AL773563

UniProtKB/TrEMBL

Z4YLB0

Conserved Domains (1) summary

cl11394
Location:60 → 287

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
NM_030718.6 → NP_109643.3 histo-blood group ABO system transferase isoform a

See identical proteins and their annotated locations for NP_109643.3

Status: VALIDATED

Source sequence(s)

AL773563

Consensus CDS

CCDS15811.1

UniProtKB/Swiss-Prot

A2AL98, P38649, Q8BZH3, Q8BZQ6, Q9EQW2, Q9EQW3

UniProtKB/TrEMBL

Z4YLB0

Related

ENSMUSP00000099964.2, ENSMUST00000102900.2

Conserved Domains (1) summary

pfam03414
Location:45 → 332

Glyco_transf_6; Glycosyltransferase family 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

26732508..26754973 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498456.4 → XP_006498519.1 histo-blood group ABO system transferase isoform X1

UniProtKB/TrEMBL

Z4YLB0

Conserved Domains (1) summary

cl11394
Location:102 → 389

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
XM_006498458.4 → XP_006498521.1 histo-blood group ABO system transferase isoform X2

Conserved Domains (1) summary

cl11394
Location:16 → 246

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold