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    SLC23A2 solute carrier family 23 member 2 [ Homo sapiens (human) ]

    Gene ID: 9962, updated on 9-Dec-2024

    Summary

    Official Symbol
    SLC23A2provided by HGNC
    Official Full Name
    solute carrier family 23 member 2provided by HGNC
    Primary source
    HGNC:HGNC:10973
    See related
    Ensembl:ENSG00000089057 MIM:603791; AllianceGenome:HGNC:10973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NBTL1; SVCT2; YSPL2; SLC23A1
    Summary
    The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in adrenal (RPKM 40.7), brain (RPKM 20.8) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC23A2 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (4852358..5010313, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (4891820..5049741, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (4833004..4990959, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372511 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:4760952-4761170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4775280-4776140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4776141-4777001 Neighboring gene Ras association domain family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17498 Neighboring gene uncharacterized LOC107985392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4816447-4816946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:4874687-4875187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4877415-4877936 Neighboring gene Sharpr-MPRA regulatory region 14391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12650 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:4953768-4954967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4979144-4979644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12651 Neighboring gene SLC23A2 promoter P2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17504 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:4983486-4984137 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:4984138-4984788 Neighboring gene SLC23A2 promoter P1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:5008813-5009342 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:5013735-5013892 Neighboring gene ribosomal protein S21 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:5025885-5026104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17505 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:5041439-5042638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5046523-5047023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:5053633-5054152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:5054153-5054671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5062418-5062918 Neighboring gene transmembrane protein 230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17509 Neighboring gene RNA, 5S ribosomal pseudogene 474

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0238

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-ascorbate:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-ascorbate:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-ascorbic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-ascorbic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-ascorbic acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in L-ascorbic acid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in L-ascorbic acid metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in L-ascorbic acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-ascorbic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in blood circulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 23 member 2
    Names
    Na(+)/L-ascorbic acid transporter 2
    nucleobase transporter-like 1 protein
    sodium-dependent vitamin C transporter-2
    solute carrier family 23 (ascorbic acid transporter), member 2
    solute carrier family 23 (nucleobase transporters), member 1
    solute carrier family 23 (nucleobase transporters), member 2
    testicular secretory protein Li 48
    yolk sac permease-like molecule 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029959.2 RefSeqGene

      Range
      13784..162936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005116.6NP_005107.4  solute carrier family 23 member 2

      See identical proteins and their annotated locations for NP_005107.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) occurs more frequently. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI742576, AL121890, BC013112, D87075
      Consensus CDS
      CCDS13085.1
      UniProtKB/Swiss-Prot
      B4DJZ1, Q8WWR4, Q92512, Q96D54, Q9UGH3, Q9UNU1, Q9UP85
      UniProtKB/TrEMBL
      A0A140VK48, A0MSJ5
      Related
      ENSP00000344322.1, ENST00000338244.6
      Conserved Domains (1) summary
      pfam00860
      Location:103531
      Xan_ur_permease; Permease family
    2. NM_203327.2NP_976072.1  solute carrier family 23 member 2

      See identical proteins and their annotated locations for NP_976072.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AF164142, AI742576, AL121890, BC013112, D87075
      Consensus CDS
      CCDS13085.1
      UniProtKB/Swiss-Prot
      B4DJZ1, Q8WWR4, Q92512, Q96D54, Q9UGH3, Q9UNU1, Q9UP85
      UniProtKB/TrEMBL
      A0A140VK48, A0MSJ5
      Related
      ENSP00000368637.1, ENST00000379333.5
      Conserved Domains (1) summary
      pfam00860
      Location:103531
      Xan_ur_permease; Permease family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      4852358..5010313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      4891820..5049741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)