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    LANCL1 LanC like glutathione S-transferase 1 [ Homo sapiens (human) ]

    Gene ID: 10314, updated on 3-Dec-2024

    Summary

    Official Symbol
    LANCL1provided by HGNC
    Official Full Name
    LanC like glutathione S-transferase 1provided by HGNC
    Primary source
    HGNC:HGNC:6508
    See related
    Ensembl:ENSG00000115365 MIM:604155; AllianceGenome:HGNC:6508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p40; GPR69A
    Summary
    This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
    Expression
    Ubiquitous expression in brain (RPKM 58.9), testis (RPKM 27.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LANCL1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (210431251..210477584, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (210912027..210958415, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (211295975..211341483, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907972 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:211111447-211112014 Neighboring gene LANCL1 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:211225248-211226447 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:211229754-211230953 Neighboring gene myosin light chain 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:211294046-211295245 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211307490-211308075 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211346110-211346611 Neighboring gene NANOG hESC enhancer GRCh37_chr2:211405459-211406038 Neighboring gene CPS1 intron CAGE-defined high expression enhancer 1 Neighboring gene CPS1 intron CAGE-defined high expression enhancer 2 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene CPS1 intronic transcript 1 Neighboring gene uncharacterized LOC107985978

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables glutathione binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables low-density lipoprotein particle receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptide modification IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glutathione S-transferase LANCL1
    Names
    40 kDa erythrocyte membrane protein
    G protein-coupled receptor 69A
    LanC (bacterial lantibiotic synthetase component C)-like 1
    LanC (bacterial lantibiotic synthetase component)
    LanC lantibiotic synthetase component C-like 1
    LanC like 1
    lanC-like protein 1
    NP_001130046.1
    NP_001130047.1
    NP_006046.1
    XP_005246300.1
    XP_054196149.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136574.2NP_001130046.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001130046.1

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC007970, BC028685, BX473106
      Consensus CDS
      CCDS2392.1
      UniProtKB/Swiss-Prot
      O43813
      UniProtKB/TrEMBL
      A0A024R453, B2R602, Q53TN2, Q6FHH6
      Related
      ENSP00000233714.4, ENST00000233714.8
      Conserved Domains (2) summary
      cd04794
      Location:62395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:189
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
    2. NM_001136575.2NP_001130047.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001130047.1

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC007970, AK312381, BX473106, DC321883
      Consensus CDS
      CCDS2392.1
      UniProtKB/Swiss-Prot
      O43813
      UniProtKB/TrEMBL
      A0A024R453, B2R602, Q53TN2, Q6FHH6
      Related
      ENSP00000397646.2, ENST00000431941.6
      Conserved Domains (2) summary
      cd04794
      Location:62395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:189
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
    3. NM_006055.3NP_006046.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_006046.1

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC007970, BX473106, DC324843, Y11395
      Consensus CDS
      CCDS2392.1
      UniProtKB/Swiss-Prot
      O43813
      UniProtKB/TrEMBL
      A0A024R453, B2R602, Q53TN2, Q6FHH6
      Related
      ENSP00000393597.2, ENST00000450366.7
      Conserved Domains (2) summary
      cd04794
      Location:62395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:189
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      210431251..210477584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246243.3XP_005246300.1  glutathione S-transferase LANCL1 isoform X1

      See identical proteins and their annotated locations for XP_005246300.1

      UniProtKB/TrEMBL
      B2R602, Q6FHH6
      Conserved Domains (2) summary
      cd04794
      Location:74407
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:13101
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      210912027..210958415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340174.1XP_054196149.1  glutathione S-transferase LANCL1 isoform X1

      UniProtKB/TrEMBL
      B2R602, Q6FHH6