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    ZNF37A zinc finger protein 37A [ Homo sapiens (human) ]

    Gene ID: 7587, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF37Aprovided by HGNC
    Official Full Name
    zinc finger protein 37Aprovided by HGNC
    Primary source
    HGNC:HGNC:13102
    See related
    Ensembl:ENSG00000075407 MIM:616085; AllianceGenome:HGNC:13102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX21; ZNF37
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.1), endometrium (RPKM 2.4) and 25 other tissues See more
    Orthologs
    all
    NEW
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    Genomic context

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    See ZNF37A in Genome Data Viewer
    Location:
    10p11.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (38094337..38150293)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (38138318..38194251)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38383265..38439221)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3274 Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 2 Neighboring gene uncharacterized LOC105376500 Neighboring gene cyclin Y like 4 (pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1. Gauthier M, et al. Hum Mol Genet, 2013 Dec 20. PMID 23922231
    2. ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer. Liu J, et al. Oncogene, 2021 May. PMID 33875786
    3. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. Guy J, et al. Genome Res, 2003 Feb. PMID 12566394, Free PMC Article
    4. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe A, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464732, Free PMC Article
    5. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-beta axis in colorectal cancer.
      Title: ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer.
    2. This suggests that the pathological molecular mechanisms linking ZNF37A and myogenesis may involve the signaling pathway that is known to promote myoblast recruitment during development and regeneration
      Title: A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ3472

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 37A
    Names
    zinc finger protein 37a (KOX 21)
    zinc finger protein KOX21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007094.4 → NP_001007095.1  zinc finger protein 37A isoform a

      See identical proteins and their annotated locations for NP_001007095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Related
      ENSP00000329141.3, ENST00000351773.7
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001178101.3 → NP_001171572.1  zinc finger protein 37A isoform a

      See identical proteins and their annotated locations for NP_001171572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment and uses a different splice site in the 5' UTR, compared to variant 1. Variants 1-10 all encode the same protein.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001324245.3 → NP_001311174.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1-3 and 5-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001324246.3 → NP_001311175.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1-4 and 6-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001324247.3 → NP_001311176.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1-5 and 7-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001324248.3 → NP_001311177.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1-6 and 8-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001324249.3 → NP_001311178.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 1-7 and 9-10, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001324250.3 → NP_001311179.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Related
      ENSP00000508865.1, ENST00000685332.1
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001324251.3 → NP_001311180.1  zinc finger protein 37A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1-9, encodes isoform a.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    10. NM_001324252.2 → NP_001311181.1  zinc finger protein 37A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 12 and 13, encodes isoform b.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box

    11. NM_001324253.2 → NP_001311182.1  zinc finger protein 37A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 11 and 13, encodes isoform b.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box

    12. NM_001324254.2 → NP_001311183.1  zinc finger protein 37A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 11 and 12, encodes isoform b.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box

    13. NM_001324256.2 → NP_001311185.1  zinc finger protein 37A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 15-16, encodes isoform c.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS81451.1
      UniProtKB/TrEMBL
      A0A1B0GVV4
      Related
      ENSP00000490669.1, ENST00000638053.1

    14. NM_001324257.2 → NP_001311186.1  zinc finger protein 37A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform c.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS81451.1
      UniProtKB/TrEMBL
      A0A1B0GVV4

    15. NM_001324258.2 → NP_001311187.1  zinc finger protein 37A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 14-15, encodes isoform c.
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS81451.1
      UniProtKB/TrEMBL
      A0A1B0GVV4

    16. NM_001324259.3 → NP_001311188.1  zinc finger protein 37A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) and variant 18 both encode isoform d.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box

    17. NM_001324260.3 → NP_001311189.1  zinc finger protein 37A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) and variant 17 both encode isoform d.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box

    18. NM_001324261.2 → NP_001311190.1  zinc finger protein 37A isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) and variant 20 both encode isoform e.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box

    19. NM_001324262.2 → NP_001311191.1  zinc finger protein 37A isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) and variant 19 both encode isoform e.
      Source sequence(s)
      AL117339
      Conserved Domains (1) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box

    20. NM_003421.4 → NP_003412.1  zinc finger protein 37A isoform a

      See identical proteins and their annotated locations for NP_003412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AL117339
      Consensus CDS
      CCDS31183.1
      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Related
      ENSP00000354377.4, ENST00000361085.9
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      38094337..38150293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425722.1 → XP_047281678.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88

    2. XM_011519656.3 → XP_011517958.1  zinc finger protein 37A isoform X1

      See identical proteins and their annotated locations for XP_011517958.1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011519657.3 → XP_011517959.1  zinc finger protein 37A isoform X1

      See identical proteins and their annotated locations for XP_011517959.1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    4. XM_011519658.4 → XP_011517960.1  zinc finger protein 37A isoform X1

      See identical proteins and their annotated locations for XP_011517960.1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:269 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:426 → 448
      zf-H2C2_2; Zinc-finger double domain

    5. XM_017016624.1 → XP_016872113.1  zinc finger protein 37A isoform X5

      Related
      ENST00000479469.5
      Conserved Domains (1) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box

    6. XM_047425724.1 → XP_047281680.1  zinc finger protein 37A isoform X4

    7. XM_047425723.1 → XP_047281679.1  zinc finger protein 37A isoform X3

    8. XM_005252586.5 → XP_005252643.1  zinc finger protein 37A isoform X2

      See identical proteins and their annotated locations for XP_005252643.1

      Conserved Domains (3) summary
      COG5048
      Location:55 → 471
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:307 → 331
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      38138318..38194251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366696.1 → XP_054222671.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88

    2. XM_054366695.1 → XP_054222670.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88

    3. XM_054366698.1 → XP_054222673.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88

    4. XM_054366697.1 → XP_054222672.1  zinc finger protein 37A isoform X1

      UniProtKB/Swiss-Prot
      B3KRQ3, D3DRZ3, P17032, Q96B88

    5. XM_054366702.1 → XP_054222677.1  zinc finger protein 37A isoform X5

    6. XM_054366701.1 → XP_054222676.1  zinc finger protein 37A isoform X4

    7. XM_054366700.1 → XP_054222675.1  zinc finger protein 37A isoform X3

    8. XM_054366699.1 → XP_054222674.1  zinc finger protein 37A isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17032.3 GenPept UniProtKB/Swiss-Prot:P17032

    Gene LinkOut

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