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    NAMPT nicotinamide phosphoribosyltransferase [ Homo sapiens (human) ]

    Gene ID: 10135, updated on 3-Dec-2024

    Summary

    Official Symbol
    NAMPTprovided by HGNC
    Official Full Name
    nicotinamide phosphoribosyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:30092
    See related
    Ensembl:ENSG00000105835 MIM:608764; AllianceGenome:HGNC:30092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
    Summary
    This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in appendix (RPKM 222.0), bone marrow (RPKM 154.0) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NAMPT in Genome Data Viewer
    Location:
    7q22.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (106248298..106285888, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (107563712..107602631, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (105888744..105925429, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901719 Neighboring gene RNA, U6 small nuclear 392, pseudogene Neighboring gene MPRA-validated peak6672 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:105900446-105900972 Neighboring gene NANOG hESC enhancer GRCh37_chr7:105900973-105901497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18533 Neighboring gene NAMPT antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18534 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:105960332-105961531 Neighboring gene LARP1B pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:105986583-105987782 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:106014918-106015131 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:106041193-106041886 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:106065201-106066400 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:106089346-106090545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26485 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:106206739-106207704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:106207705-106208670 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:106208671-106209636 Neighboring gene uncharacterized CTB-30L5.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
    tat HIV-1 Tat-induced inhibition of NAMPT protein expression and depletion of NAD(+) levels in TZM-bl cells are reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
    tat HIV-1 Tat upregulates miR-182 in TZM-bl cells. MiR-182 significantly inhibits NAMPT protein expression by acting on the 3'-UTR of the NAMPT mRNA PubMed
    tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117256, DKFZp666B131

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nicotinamide phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nicotinamide phosphoribosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    nicotinamide phosphoribosyltransferase
    Names
    NAmPRTase
    pre-B cell-enhancing factor
    pre-B-cell colony-enhancing factor 1
    NP_005737.1
    XP_047275655.1
    XP_047275656.1
    XP_054212959.1
    XP_054212960.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005746.3NP_005737.1  nicotinamide phosphoribosyltransferase precursor

      See identical proteins and their annotated locations for NP_005737.1

      Status: REVIEWED

      Source sequence(s)
      AC007032, AI299587, BC106046, U02020
      Consensus CDS
      CCDS5737.1
      UniProtKB/Swiss-Prot
      A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95
      UniProtKB/TrEMBL
      A0A7P0T895
      Related
      ENSP00000222553.3, ENST00000222553.8
      Conserved Domains (1) summary
      cd01569
      Location:12428
      PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      106248298..106285888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419699.1XP_047275655.1  nicotinamide phosphoribosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95
      UniProtKB/TrEMBL
      A0A7P0T895
      Related
      ENSP00000390591.2, ENST00000424768.2
    2. XM_047419700.1XP_047275656.1  nicotinamide phosphoribosyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A7P0T941, A0A7P0Z466
      Related
      ENSP00000505390.1, ENST00000681391.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      107563712..107602631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356984.1XP_054212959.1  nicotinamide phosphoribosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      A4D0Q9, A4D0R0, P43490, Q3KQV0, Q8WW95
      UniProtKB/TrEMBL
      A0A7P0T895
    2. XM_054356985.1XP_054212960.1  nicotinamide phosphoribosyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A7P0T941, A0A7P0Z466

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182790.1: Suppressed sequence

      Description
      NM_182790.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.