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    PTC4 type 2C protein phosphatase PTC4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PTC4
    Official Full Name
    type 2C protein phosphatase PTC4
    Primary source
    SGD:S000000329
    Locus tag
    YBR125C
    See related
    AllianceGenome:SGD:S000000329; FungiDB:YBR125C; VEuPathDB:YBR125C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GCT1
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Located in cytoplasm. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PTC4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (487199..488380, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL36 Neighboring gene transcription factor TFIIIC subunit TFC1 Neighboring gene alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 Neighboring gene Meo1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae. Lee JW, et al. Sci Rep, 2021 Dec 17. PMID 34921163, Free PMC Article
    2. Effects of deletion of different PP2C protein phosphatase genes on stress responses in Saccharomyces cerevisiae. Sharmin D, et al. Yeast, 2014 Oct. PMID 25088474
    3. Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiae. Shitamukai A, et al. J Biol Chem, 2004 Jan 30. PMID 14583627
    4. A series of protein phosphatase gene disruptants in Saccharomyces cerevisiae. Sakumoto N, et al. Yeast, 1999 Nov. PMID 10572263
    5. Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Cheng A, et al. Genes Dev, 1999 Nov 15. PMID 10580002, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
      Title: Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    type 2C protein phosphatase PTC4
    NP_009683.1
    • Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      487199..488380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178473.1 → NP_009683.1  TPA: type 2C protein phosphatase PTC4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009683.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQC2, P38089
      UniProtKB/TrEMBL
      A6ZL69, B3LN31, B5VE84, C7GY08, D3UEL7, G2W9C9, N1P6P0
      Conserved Domains (1) summary
      pfam00481
      Location:82 → 355
      PP2C; Protein phosphatase 2C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38089.1

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