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    OPY1 Opy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OPY1
    Official Full Name
    Opy1p
    Primary source
    SGD:S000000333
    Locus tag
    YBR129C
    See related
    AllianceGenome:SGD:S000000333; FungiDB:YBR129C; VEuPathDB:YBR129C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OPY1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (494353..495339, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit B Neighboring gene Atg14p Neighboring gene She3p Neighboring gene Ccz1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis. Ling Y, et al. EMBO J, 2012 Jun 29. PMID 22562153, Free PMC Article
    2. Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. Szentpetery Z, et al. BMC Cell Biol, 2009 Sep 21. PMID 19769794, Free PMC Article
    3. A PhotoClick cholesterol-based quantitative proteomics screen for cytoplasmic sterol-binding proteins in Saccharomyces cerevisiae. Chauhan N, et al. Yeast, 2020 Jan. PMID 31758572
    4. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Edwards MC, et al. Genetics, 1997 Nov. PMID 9383053, Free PMC Article
    5. A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Gallego O, et al. Mol Syst Biol, 2010 Nov 30. PMID 21119626, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Opy1p
    NP_009687.1
    • hypothetical protein; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      494353..495339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178477.1 → NP_009687.1  TPA: Opy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQC6, P38271
      UniProtKB/TrEMBL
      A6ZL73, B3LN27, B5VE89, C7GY12, D3UEM2, G2W9D3, N1PAT4
      Conserved Domains (1) summary
      cl17171
      Location:214 → 315
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38271.1

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