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    CCZ1 Ccz1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCZ1
    Official Full Name
    Ccz1p
    Primary source
    SGD:S000000335
    Locus tag
    YBR131W
    See related
    AllianceGenome:SGD:S000000335; FungiDB:YBR131W; VEuPathDB:YBR131W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CVT16
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-5-phosphate binding activity; and phosphatidylserine binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in autophagosome maturation; protein targeting to vacuole; and vesicle docking. Located in late endosome. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CCZ1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (497163..499277)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Opy1p Neighboring gene She3p Neighboring gene Agp2p Neighboring gene protein arginine N-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ccz1p/Aut11p/Cvt16p is essential for autophagy and the cvt pathway. Meiling-Wesse K, et al. FEBS Lett, 2002 Aug 28. PMID 12208507
    2. The novel protein Ccz1p required for vacuolar assembly in Saccharomyces cerevisiae functions in the same transport pathway as Ypt7p. Kucharczyk R, et al. J Cell Sci, 2000 Dec. PMID 11069774
    3. The Ccz1 protein interacts with Ypt7 GTPase during fusion of multiple transport intermediates with the vacuole in S. cerevisiae. Kucharczyk R, et al. J Cell Sci, 2001 Sep. PMID 11590240
    4. The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. Wang CW, et al. J Biol Chem, 2002 Dec 6. PMID 12364329, Free PMC Article
    5. The yeast genes, ARL1 and CCZ1, interact to control membrane traffic and ion homeostasis. Love SL, et al. Biochem Biophys Res Commun, 2004 Jul 2. PMID 15184059

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors find that Mon1-Ccz1 directly binds to Atg8, the yeast homolog of the members of the mammalian LC3 protein family.
      Title: Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure.
    2. Guanine nucleotide exchange factor activity of the Mon1-Ccz1 complex towards Ypt7 requires the interface formed by their longin domains.
      Title: The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.
    3. Data indicate that the Mon1-Ccz1 complex triggers endosomal maturation by activating Ypt7 on late endosomes.
      Title: The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.
    4. These results suggest that the Ccz1p-Mon1p-Ypt7p complex is involved in fusion of transport vesicles to multiple target membranes in yeast cells.
      Title: The Saccharomyces cerevisiae protein Ccz1p interacts with components of the endosomal fusion machinery.
    5. vacuolar sorting protein Ccz1p has multiple functions in Saccharomyces cerevisiae
      Title: Multiple functions of the vacuolar sorting protein Ccz1p in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuolar membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuolar membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Mon1-Ccz1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Mon1-Ccz1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in multivesicular body membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ccz1p
    NP_009689.3
    • Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      497163..499277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178479.3 → NP_009689.3  TPA: Ccz1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009689.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQC8, P38273
      UniProtKB/TrEMBL
      G2W9D5, N1P9H2
      Conserved Domains (1) summary
      pfam08217
      Location:6 → 703
      DUF1712; Fungal domain of unknown function (DUF1712)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38273.1

    Gene LinkOut

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