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    AAR2 U5 snRNP complex subunit AAR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AAR2
    Official Full Name
    U5 snRNP complex subunit AAR2
    Primary source
    SGD:S000000170
    Locus tag
    YBL074C
    See related
    AllianceGenome:SGD:S000000170; FungiDB:YBL074C; VEuPathDB:YBL074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in spliceosomal tri-snRNP complex assembly. Part of U5 snRNP. Orthologous to human AAR2 (AAR2 splicing factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AAR2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (86722..87789, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene isoleucine--tRNA ligase ILS1 Neighboring gene Hsp70 family ATPase SSA3 Neighboring gene ncRNA Neighboring gene ribosomal 40S subunit protein S8A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae. Nakazawa N, et al. Mol Cell Biol, 1991 Nov. PMID 1922071, Free PMC Article
    2. Crystallization and biochemical characterization of the human spliceosomal Aar2-Prp8(RNaseH) complex. Santos K, et al. Acta Crystallogr F Struct Biol Commun, 2015 Nov. PMID 26527271, Free PMC Article
    3. Crystal structure of Prp8 reveals active site cavity of the spliceosome. Galej WP, et al. Nature, 2013 Jan 31. PMID 23354046, Free PMC Article
    4. Mechanism for Aar2p function as a U5 snRNP assembly factor. Weber G, et al. Genes Dev, 2011 Aug 1. PMID 21764848, Free PMC Article
    5. prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast. Boon KL, et al. Nat Struct Mol Biol, 2007 Nov. PMID 17934474, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aar2p regulates both protein and RNA binding to Prp8p during U5 snRNP assembly
      Title: Structural basis for dual roles of Aar2p in U5 snRNP assembly.
    2. Prp8 interaction sites with Aar2 protein
      Title: Prp8p dissection reveals domain structure and protein interaction sites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U5 snRNP complex subunit AAR2
    NP_009479.1
    • Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      86722..87789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178314.1 → NP_009479.1  TPA: U5 snRNP complex subunit AAR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009479.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPS8, P32357
      UniProtKB/TrEMBL
      A6ZKM7, B3LNK7, B5VDR6, C7GK59, C8Z3R9, G2W8T7, N1P8G2
      Conserved Domains (2) summary
      cd13778
      Location:175 → 313
      Aar2_C; C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      pfam05282
      Location:3 → 283
      AAR2; AAR2 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32357.1

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