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    UIP4 Uip4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UIP4
    Official Full Name
    Uip4p
    Primary source
    SGD:S000006107
    Locus tag
    YPL186C
    See related
    AllianceGenome:SGD:S000006107; FungiDB:YPL186C; VEuPathDB:YPL186C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within nuclear envelope organization. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UIP4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (194512..195426, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene NADH kinase Neighboring gene Mf(Alpha)1p Neighboring gene Mrn1p Neighboring gene putative mitochondrial 54S ribosomal protein RTC6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uip4p modulates nuclear pore complex function in Saccharomyces cerevisiae. Deolal P, et al. Nucleus, 2022 Dec. PMID 35171083, Free PMC Article
    2. Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins. Takahashi Y, et al. J Biochem, 2000 Nov. PMID 11056382
    3. Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Reinders J, et al. Mol Cell Proteomics, 2007 Nov. PMID 17761666
    4. Pex35 is a regulator of peroxisome abundance. Yofe I, et al. J Cell Sci, 2017 Feb 15. PMID 28049721, Free PMC Article
    5. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Zahedi RP, et al. Mol Biol Cell, 2006 Mar. PMID 16407407, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nuclear envelope organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Uip4p
    NP_015138.1
    • Protein required for nuclear envelope integrity; involved in distribution of nuclear pore complexes; interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      194512..195426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184000.1 → NP_015138.1  TPA: Uip4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015138.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3I3, Q08926
      UniProtKB/TrEMBL
      A6ZW68, B3LKP3, B5VSY9, C8ZIJ2, N1NVN8
      Conserved Domains (2) summary
      cd02859
      Location:1 → 87
      E_set_AMPKbeta_like_N; N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
      COG5271
      Location:73 → 271
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08926.1

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