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    Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305178, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hnrnpdlprovided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein D-likeprovided by RGD
    Primary source
    RGD:1309950
    See related
    EnsemblRapid:ENSRNOG00000002270 AllianceGenome:RGD:1309950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrpdl; hnRNP DL
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in regulation of gene expression. Predicted to be located in chromatin and nucleus. Predicted to be active in nucleoplasm and synapse. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 3. Orthologous to human HNRNPDL (heterogeneous nuclear ribonucleoprotein D like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 364.6), Spleen (RPKM 248.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpdl in Genome Data Viewer
    Location:
    14p22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9861716..9867945)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9557430..9563659)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (11199114..11204670)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 150C Neighboring gene uncharacterized LOC134481706 Neighboring gene uncharacterized LOC134481708 Neighboring gene enolase-phosphatase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene histone chaperone ASF1A-like Neighboring gene transcription factor BTF3-like Neighboring gene vesicle-associated membrane protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a mouse heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its tissue-specific expression. Akagi T, et al. Gene, 2000 Mar 21. PMID 10717477
    2. Cloning and characterization of a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein-like protein and its expression in myeloid leukemia cells. Tsuchiya N, et al. J Biochem, 1998 Mar. PMID 9538234
    3. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125262

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein D-like
    Names
    hnRNP D-like
    hnRNP-DL
    hnRPD-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033696.2 → NP_001028868.1  heterogeneous nuclear ribonucleoprotein D-like isoform 1

      See identical proteins and their annotated locations for NP_001028868.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q3SWU3
      UniProtKB/TrEMBL
      A6K617
      Related
      ENSRNOP00000003106.5, ENSRNOT00000003106.8
      Conserved Domains (2) summary
      cd12585
      Location:137 → 211
      RRM2_hnRPDL; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
      cd12758
      Location:52 → 127
      RRM1_hnRPDL; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

    2. NM_001401448.1 → NP_001388377.1  heterogeneous nuclear ribonucleoprotein D-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q3SWU3

    3. NM_001401449.1 → NP_001388378.1  heterogeneous nuclear ribonucleoprotein D-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2KAZ7

    4. NM_001401450.1 → NP_001388379.1  heterogeneous nuclear ribonucleoprotein D-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2KAZ7
      Related
      ENSRNOP00000075589.1, ENSRNOT00000079767.3

    5. NM_001401451.1 → NP_001388380.1  heterogeneous nuclear ribonucleoprotein D-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2KAZ7

    RNA

    1. NR_174877.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      9861716..9867945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273051.1 → XP_063129121.1  heterogeneous nuclear ribonucleoprotein D-like isoform X1

    2. XM_063273052.1 → XP_063129122.1  heterogeneous nuclear ribonucleoprotein D-like isoform X2

    RNA

    1. XR_005492930.2 RNA Sequence

    2. XR_359349.5 RNA Sequence

    3. XR_010057363.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SWU3.1 GenPept UniProtKB/Swiss-Prot:Q3SWU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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