Rbm5 RNA binding motif protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbm5provided by RGD
Official Full Name: RNA binding motif protein 5provided by RGD
Primary source: RGD:1305059
See related: EnsemblRapid:ENSRNOG00000018153 AllianceGenome:RGD:1305059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; and spliceosomal complex assembly. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Orthologous to human RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 483.9), Spleen (RPKM 372.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117298866..117328107, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108420220..108449481, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116502941..116532178, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBM5 regulates Rab4a in rat neurons
Title: Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons.
findings indicate that RBM5 promotes neuronal apoptosis through modulating p53 signaling pathway following SCI.
Title: RBM5 and p53 expression after rat spinal cord injury: implications for neuronal apoptosis.
This work establishes myoblast differentiation as a relevant model in which to conduct functional studies regarding Rbm5 and Rbm10.
Title: Differential downregulation of Rbm5 and Rbm10 during skeletal and cardiac differentiation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in spliceosomal complex assembly	IEA Inferred from Electronic Annotation more info
involved_in spliceosomal complex assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal complex assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100548.2 → NP_001094018.1 RNA-binding protein 5 isoform 1

See identical proteins and their annotated locations for NP_001094018.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

B2GV05

UniProtKB/TrEMBL

A0A8L2R731

Related

ENSRNOP00000024529.7, ENSRNOT00000024529.8

Conserved Domains (6) summary

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:455 → 510

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:181 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:743 → 787

G-patch; G-patch domain

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)
NM_001433315.1 → NP_001420244.1 RNA-binding protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

B2GV05
NM_001433316.1 → NP_001420245.1 RNA-binding protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

B2GV05
NM_001433317.1 → NP_001420246.1 RNA-binding protein 5 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

117298866..117328107 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243739.5 → XP_006243801.1 RNA-binding protein 5 isoform X1

Conserved Domains (6) summary

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:455 → 510

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:181 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:743 → 787

G-patch; G-patch domain

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)
XM_006243738.5 → XP_006243800.1 RNA-binding protein 5 isoform X1

Conserved Domains (6) summary

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:455 → 510

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:181 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:743 → 787

G-patch; G-patch domain

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)
XM_039081222.2 → XP_038937150.1 RNA-binding protein 5 isoform X1

UniProtKB/Swiss-Prot

B2GV05

UniProtKB/TrEMBL

A0A8L2R731

Conserved Domains (6) summary

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:455 → 510

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:181 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:743 → 787

G-patch; G-patch domain

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)
XM_039081223.2 → XP_038937151.1 RNA-binding protein 5 isoform X2

Conserved Domains (5) summary

sd00025
Location:13 → 32

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:283 → 338

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:9 → 38

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:571 → 615

G-patch; G-patch domain

cd12755
Location:57 → 142

RRM2_RBM5; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 5 (RBM5)
XM_063265245.1 → XP_063121315.1 RNA-binding protein 5 isoform X3