Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab3gap1provided by RGD
Official Full Name: RAB3 GTPase activating protein catalytic subunit 1provided by RGD
Primary source: RGD:1306487
See related: EnsemblRapid:ENSRNOG00000003953 AllianceGenome:RGD:1306487
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rab3-GAP; RGD1306487
Summary: Enables GTPase activator activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; positive regulation of macromolecule metabolic process; and positive regulation of organelle organization. Located in excitatory synapse. Human ortholog(s) of this gene implicated in Warburg micro syndrome 1. Orthologous to human RAB3GAP1 (RAB3 GTPase activating protein catalytic subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 248.7), Heart (RPKM 206.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (41908179..41981611)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (39355698..39429154)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (44578208..44649876)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D13Hmgc85 (e-PCR)
- UniSTS:530703

UniSTS:234205 (e-PCR)
- UniSTS:234205

BF398383 (e-PCR)
- UniSTS:246774

AI013755 (e-PCR)
- UniSTS:250366

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	IEA Inferred from Electronic Annotation more info
involved_in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in face morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hypothalamus development	IEA Inferred from Electronic Annotation more info
involved_in hypothalamus development	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid droplet organization	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endoplasmic reticulum tubular network organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endoplasmic reticulum tubular network organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endoplasmic reticulum tubular network organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein lipidation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein lipidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of calcium ion-dependent exocytosis of neurotransmitter	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion-dependent exocytosis of neurotransmitter	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of short-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of short-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum tubular network	ISS Inferred from Sequence or Structural Similarity more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rab3 GTPase-activating protein catalytic subunit

Names: RAB3 GTPase activating protein subunit 1; RAB3 GTPase-activating protein 130 kDa subunit; rab3-GAP p130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.