Katna1 katanin p60 (ATPase-containing) subunit A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Katna1provided by MGI
Official Full Name: katanin p60 (ATPase-containing) subunit A1provided by MGI
Primary source: MGI:MGI:1344353
See related: Ensembl:ENSMUSG00000019794 AllianceGenome:MGI:1344353
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables ATP hydrolysis activity and dynein complex binding activity. Acts upstream of or within microtubule cytoskeleton organization; neuron migration; and protein localization. Located in several cellular components, including axon; centrosome; and lipid droplet. Is expressed in several structures, including brain; genitourinary system; intestine; liver; and spleen. Orthologous to human KATNA1 (katanin catalytic subunit A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.5), placenta adult (RPKM 5.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 2.32 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (7601748..7638913)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (7725990..7763150)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.
Title: The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility.
Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules.
Title: Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules.
Study uncovered an unexpected role of the p60-MIT and p80-CTD domains of katanin in the oligomerization and regulation of the protein. p80-CTD mediates the assembly of p60-MIT:p80-CTD heterodimers into heterotetramers that have an impact on katanin MT end and lattice binding as well as on the severing activity of the enzyme. The heterotetrameric structure of the p60-MIT:p80-CTD K555A/R591A mutant revealed a domain swap.
Title: Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex.
This study structurally and functionally characterized the interaction between the two katanin subunits that is mediated by the p60-MIT domain and the p80 C-terminal domain (p80-CTD). p60-MIT and p80-CTD form a tight heterodimeric complex, whose high-resolution structure was determined by X-ray crystallography.
Title: Structural basis of katanin p60:p80 complex formation.
Our results suggest that LECT2 regulates neuritic extension through microtubular morphallaxis through the control of katanin-P60 levels.
Title: Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology.
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization
Title: A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables dynein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule severing ATPase activity	IEA Inferred from Electronic Annotation more info
enables microtubule severing ATPase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoplasmic microtubule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule bundle formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule severing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule severing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule severing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
part_of katanin complex	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: katanin p60 ATPase-containing subunit A1

Names: katanin p60 subunit A1; lipotransin; p60 katanin

NP_035965.3

EC 5.6.1.1

XP_030100951.1

EC 5.6.1.1

XP_036011678.1

EC 5.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011835.3 → NP_035965.3 katanin p60 ATPase-containing subunit A1

Status: VALIDATED

Source sequence(s)

AC156391

Consensus CDS

CCDS23689.2

UniProtKB/TrEMBL

E9QKG2

Related

ENSMUSP00000019929.7, ENSMUST00000019929.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

7601748..7638913

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155785.1 → XP_036011678.1 katanin p60 ATPase-containing subunit A1 isoform X1

Conserved Domains (3) summary

pfam09336
Location:366 → 399

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:313 → 357

AAA_lid_3; AAA+ lid domain

cd19522
Location:120 → 289

RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1
XM_030245091.2 → XP_030100951.1 katanin p60 ATPase-containing subunit A1 isoform X2

Conserved Domains (1) summary

COG0464
Location:3 → 256

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]