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    Mylk2 myosin light chain kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117558, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mylk2provided by RGD
    Official Full Name
    myosin light chain kinase 2provided by RGD
    Primary source
    RGD:620934
    See related
    EnsemblRapid:ENSRNOG00000008235 AllianceGenome:RGD:620934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Klmc; Mlck
    Summary
    Enables myosin light chain binding activity and myosin light chain kinase activity. Involved in several processes, including positive regulation of fast-twitch skeletal muscle fiber contraction; regulation of neuronal synaptic plasticity; and synaptic vesicle transport. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (myosin light chain kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1336.8) See more
    Orthologs
    NEW
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    Genomic context

    See Mylk2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161836705..161848609)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141376450..141388357)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148386185..148397851)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U109 Neighboring gene TPX2, microtubule nucleation factor Neighboring gene uncharacterized LOC102553350 Neighboring gene forkhead box S1 Neighboring gene dual specificity phosphatase 15 Neighboring gene tubulin tyrosine ligase like 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin light chain binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables myosin light chain kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin light chain kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables myosin light chain kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin light chain kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables myosin light chain kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle contraction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neuromuscular synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuromuscular synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fast-twitch skeletal muscle fiber contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of muscle filament sliding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of muscle filament sliding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle satellite cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle satellite cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in striated muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in striated muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in water transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myosin light chain kinase 2, skeletal/cardiac muscle
    Names
    MLCK2
    myosin light chain kinase 2, skeletal muscle
    myosin, light polypeptide kinase 2
    NP_476557.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057209.2NP_476557.2  myosin light chain kinase 2, skeletal/cardiac muscle

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P20689
      UniProtKB/TrEMBL
      A6KHS0, G3V731
      Related
      ENSRNOP00000011255.2, ENSRNOT00000011255.7
      Conserved Domains (1) summary
      cl21453
      Location:295554
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161836705..161848609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005501754.2 RNA Sequence

    2. XR_005501755.2 RNA Sequence