Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrg2provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit gamma 2provided by RGD
Primary source: RGD:61966
See related: EnsemblRapid:ENSRNOG00000003241 AllianceGenome:RGD:61966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA-A receptor activity and chloride channel activity. Contributes to GABA receptor activity. Involved in several processes, including GABAergic synaptic transmission; cellular response to zinc ion; and response to anesthetic. Located in cell surface; dendrite membrane; and inhibitory synapse. Part of GABA receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Biomarker of fetal alcohol spectrum disorder and hepatic encephalopathy. Human ortholog(s) of this gene implicated in alcohol dependence; alcoholic liver cirrhosis; amphetamine abuse; brain disease (multiple); and heroin dependence. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 394.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (26876926..26965523, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (26374693..26463937, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (27090913..27179786, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of electroacupuncture on the expression of P2 x 4, GABAA gamma 2 and long-term potentiation in spinal cord of rats with neuropathic pain.
Title: Effect of electroacupuncture on the expression of P2 × 4, GABAA γ 2 and long-term potentiation in spinal cord of rats with neuropathic pain.
Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate alpha1beta2gamma2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone.
Title: Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABA(A) Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone.
Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats.
Title: Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats.
Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
Title: Local miRNA-Dependent Translational Control of GABA(A)R Synthesis during Inhibitory Long-Term Potentiation.
RNF34 regulates postsynaptic gamma2-GABAAR clustering and GABAergic synaptic innervation by interacting with and ubiquitinating the gamma2-GABAAR subunit promoting GABAAR degradation
Title: Ring finger protein 34 (RNF34) interacts with and promotes γ-aminobutyric acid type-A receptor degradation via ubiquitination of the γ2 subunit.
This study demonistrated that Gabrg2 receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat.
Title: GABAA receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat: implications for REM sleep control.
This study provides evidence that alpha1F64, a key aromatic residue at the GABA binding site, is involved in both the binding and gating properties of alpha1beta1gamma2 receptors.
Title: α1F64 Residue at GABA(A) receptor binding site is involved in gating by influencing the receptor flipping transitions.
Switching the intracellular domains of the gamma2 and gamma1 subunits substantiated this inference. Because this region determines post-synaptic localization, we hypothesize that GABAARs containing gamma1 and gamma2 use different mechanisms for synaptic clustering.
Title: GABAA receptor α and γ subunits shape synaptic currents via different mechanisms.
Data indicate there was an inverse correlation between depressive-like behaviors and GABA(A)R alpha1 subunit mRNA expression in the right hemisphere in female and progesterone decreased the GABA(A)R gamma2 mRNA expression only in the left hemisphere of male.
Title: Effect of progesterone on the expression of GABA(A) receptor subunits in the prefrontal cortex of rats: implications of sex differences and brain hemisphere.
The GABA A receptor alpha1-gamma2 subunit interface structure undergoes agonist-specific conformational changes.
Title: Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE120391 (e-PCR)
- UniSTS:247321

D0Uia1 (e-PCR)
- UniSTS:518537

G45867 (e-PCR)
- UniSTS:106669

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to GABA receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-A receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-A receptor activity	TAS Traceable Author Statement more info	PubMed
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-gated chloride ion channel activity	IEA Inferred from Electronic Annotation more info
contributes_to GABA-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
contributes_to GABA-gated chloride ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables GABA-gated chloride ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables inhibitory extracellular ligand-gated monoatomic ion channel activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
involved_in cellular response to histamine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to histamine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to histamine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in inhibitory synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in inhibitory synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to anesthetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of GABA receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GABA-A receptor complex	IEA Inferred from Electronic Annotation more info
part_of GABA-A receptor complex	ISO Inferred from Sequence Orthology more info
part_of GABA-A receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit gamma-2

Names: GABA(A) receptor subunit gamma-2; GABAAR subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid type A receptor gamma 2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393775.1 → NP_001380704.1 gamma-aminobutyric acid receptor subunit gamma-2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CB740905, JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K2G4, Q6PW52

Related

ENSRNOP00000004619.3, ENSRNOT00000004619.4

Conserved Domains (2) summary

TIGR00860
Location:68 → 471

LIC; Cation transporter family protein

cd19000
Location:89 → 270

LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma
NM_183327.2 → NP_899156.1 gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor

See identical proteins and their annotated locations for NP_899156.1

Status: VALIDATED

Source sequence(s)

CB740905, JAXUCZ010000010

UniProtKB/Swiss-Prot

P18508

Related

ENSRNOP00000072234.2, ENSRNOT00000082445.3

Conserved Domains (2) summary

TIGR00860
Location:68 → 463

LIC; Cation transporter family protein

cd19000
Location:89 → 270

LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma