Cfap144 cilia and flagella associated protein 144 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cfap144provided by MGI
Official Full Name: cilia and flagella associated protein 144provided by MGI
Primary source: MGI:MGI:1922679
See related: Ensembl:ENSMUSG00000049154 AllianceGenome:MGI:1922679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Theg6; Fam183b; 3100002J23Rik
Summary: Predicted to enable microtubule binding activity. Involved in flagellated sperm motility. Located in centrosome and ciliary basal body. Is active in axonemal B tubule inner sheath; ciliary base; and sperm flagellum. Is expressed in several structures, including brain ventricle and choroid plexus; gonad; notochord; respiratory system; and sensory organ. Orthologous to several human genes including CFAP144 (cilia and flagella associated protein 144). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 7.7), lung adult (RPKM 0.8) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 36.3 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (58683628..58692786, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (58783892..58802221, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Surprisingly, mice homozygous for a null allele did not display any defects indicative of disrupted motile ciliary function.
Title: The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axonemal B tubule inner sheath	IDA Inferred from Direct Assay more info	PubMed
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary base	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary base	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cilia- and flagella-associated protein 144

Names: family with sequence similarity 183, member B; protein FAM183B; testis highly expressed protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162878.3 → NP_001156350.2 cilia- and flagella-associated protein 144 isoform 2

Status: VALIDATED

Source sequence(s)

AL662903

Consensus CDS

CCDS48807.2

Related

ENSMUSP00000051960.5, ENSMUST00000060581.5

Conserved Domains (1) summary

pfam14886
Location:19 → 101

FAM183; FAM183A and FAM183B related
NM_029283.3 → NP_083559.2 cilia- and flagella-associated protein 144 isoform 1

Status: VALIDATED

Source sequence(s)

AL662903

Consensus CDS

CCDS48808.2

UniProtKB/Swiss-Prot

D2D553, Q3TZB7, Q5NC57, Q9CXW5

Related

ENSMUSP00000091708.6, ENSMUST00000094156.12

Conserved Domains (1) summary

pfam14886
Location:19 → 121

FAM183; FAM183A and FAM183B related