Stk10 serine/threonine kinase 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stk10provided by RGD
Official Full Name: serine/threonine kinase 10provided by RGD
Primary source: RGD:3779
See related: EnsemblRapid:ENSRNOG00000004217 AllianceGenome:RGD:3779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including lymphocyte aggregation; protein autophosphorylation; and regulation of lymphocyte migration. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Orthologous to human STK10 (serine/threonine kinase 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 158.9), Thymus (RPKM 139.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (17622149..17716337)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (17117860..17212065)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (17420964..17521810)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VIRMA promotes neuron apoptosis via inducing m6A methylation of STK10 in spinal cord injury animal models.
Title: VIRMA promotes neuron apoptosis via inducing m6A methylation of STK10 in spinal cord injury animal models.

Submit: New GeneRIF Correction

General gene information

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Markers

AU049011 (e-PCR)
- UniSTS:145459

AA997828 (e-PCR)
- UniSTS:248425

D10Got34 (e-PCR)
- UniSTS:115309

RH129287 (e-PCR)
- UniSTS:212594

D10Wox27 (e-PCR)
- UniSTS:239236

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lymphocyte aggregation	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lymphocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lymphocyte migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of lymphocyte migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of lymphocyte migration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase 10

NP_062079.2

EC 2.7.11.1

XP_038941664.1

EC 2.7.11.1

XP_038941665.1

EC 2.7.11.1

XP_063124879.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019206.2 → NP_062079.2 serine/threonine-protein kinase 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

H9KVF6

Related

ENSRNOP00000044325.5, ENSRNOT00000047011.6

Conserved Domains (3) summary

cd06644
Location:23 → 314

STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)

smart00220
Location:36 → 294

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12474
Location:768 → 908

PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

17622149..17716337

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085736.2 → XP_038941664.1 serine/threonine-protein kinase 10 isoform X1

UniProtKB/TrEMBL

A0A0G2K7Z9, H9KVF6

Related

ENSRNOP00000074413.2, ENSRNOT00000080404.3

Conserved Domains (2) summary

cd06644
Location:23 → 314

STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)

pfam12474
Location:600 → 738

PKK; Polo kinase kinase
XM_063268809.1 → XP_063124879.1 serine/threonine-protein kinase 10 isoform X2

UniProtKB/TrEMBL

H9KVF6
XM_039085737.2 → XP_038941665.1 serine/threonine-protein kinase 10 isoform X3

UniProtKB/TrEMBL

H9KVF6

Conserved Domains (2) summary

pfam12474
Location:494 → 632

PKK; Polo kinase kinase

cl21453
Location:2 → 208

PKc_like; Protein Kinases, catalytic domain