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    Sgk3 serum/glucocorticoid regulated kinase family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171498, updated on 9-Dec-2024

    Summary

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    Symbol
    Sgk3provided by RGD
    Full Name
    serum/glucocorticoid regulated kinase family, member 3provided by RGD
    Primary source
    RGD:620242
    See related
    EnsemblRapid:ENSRNOG00000049052 AllianceGenome:RGD:620242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cisk; Sgkl
    Summary
    Predicted to enable molecular adaptor activity; potassium channel regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in cytoplasmic vesicle. Orthologous to several human genes including SGK3 (serum/glucocorticoid regulated kinase family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 103.9), Thymus (RPKM 90.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgk3 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14128628..14255099, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9345761..9472243, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (9046889..9094740, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556004 Neighboring gene transcription factor 24 Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 4 Neighboring gene interferon-induced transmembrane protein 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MiR-155 modulates the progression of neuropathic pain through targeting SGK3. Liu S, et al. Int J Clin Exp Pathol, 2015. PMID 26823753, Free PMC Article
    2. Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival. Liu D, et al. Curr Biol, 2000 Oct 5. PMID 11050396
    3. Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. Dai F, et al. Genomics, 1999 Nov 15. PMID 10585774
    4. The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11. Lamothe SM, et al. J Biol Chem, 2013 May 24. PMID 23589291, Free PMC Article
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-155 modulates the progression of neuropathic pain through SGK3 signaling.
      Title: MiR-155 modulates the progression of neuropathic pain through targeting SGK3.
    2. SGK1,3 enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11-mediated hERG recycling.
      Title: The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Sgk3
    Names
    cytokine-independent survival kinase
    serum/glucocorticoid-regulated kinase 3
    NP_001362972.1
    XP_038965159.1
    XP_038965160.1
    XP_038965161.1
    XP_063143190.1
    XP_063143191.1
    XP_063143192.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376043.1 → NP_001362972.1  serine/threonine-protein kinase Sgk3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q8R4V0
      UniProtKB/TrEMBL
      M0R582
      Related
      ENSRNOP00000064540.3, ENSRNOT00000072210.4
      Conserved Domains (2) summary
      cd06870
      Location:12 → 120
      PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
      cd05604
      Location:165 → 490
      STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      14128628..14255099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109233.2 → XP_038965161.1  serine/threonine-protein kinase Sgk3 isoform X1

      UniProtKB/Swiss-Prot
      Q8R4V0
      UniProtKB/TrEMBL
      M0R582
      Conserved Domains (2) summary
      cd06870
      Location:12 → 120
      PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
      cd05604
      Location:165 → 490
      STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

    2. XM_063287121.1 → XP_063143191.1  serine/threonine-protein kinase Sgk3 isoform X1

      UniProtKB/Swiss-Prot
      Q8R4V0
      UniProtKB/TrEMBL
      M0R582

    3. XM_039109232.2 → XP_038965160.1  serine/threonine-protein kinase Sgk3 isoform X1

      UniProtKB/Swiss-Prot
      Q8R4V0
      UniProtKB/TrEMBL
      M0R582
      Conserved Domains (2) summary
      cd06870
      Location:12 → 120
      PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
      cd05604
      Location:165 → 490
      STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

    4. XM_039109231.2 → XP_038965159.1  serine/threonine-protein kinase Sgk3 isoform X1

      UniProtKB/Swiss-Prot
      Q8R4V0
      UniProtKB/TrEMBL
      M0R582
      Conserved Domains (2) summary
      cd06870
      Location:12 → 120
      PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
      cd05604
      Location:165 → 490
      STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

    5. XM_063287120.1 → XP_063143190.1  serine/threonine-protein kinase Sgk3 isoform X1

      UniProtKB/Swiss-Prot
      Q8R4V0
      UniProtKB/TrEMBL
      M0R582

    6. XM_063287122.1 → XP_063143192.1  serine/threonine-protein kinase Sgk3 isoform X1

      UniProtKB/Swiss-Prot
      Q8R4V0
      UniProtKB/TrEMBL
      M0R582
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4V0.2 GenPept UniProtKB/Swiss-Prot:Q8R4V0

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