Asb11 ankyrin repeat and SOCS box-containing 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asb11provided by MGI
Official Full Name: ankyrin repeat and SOCS box-containing 11provided by MGI
Primary source: MGI:MGI:1916104
See related: Ensembl:ENSMUSG00000031382 AllianceGenome:MGI:1916104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110067L12Rik; 1600009D24Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; positive regulation of protein catabolic process; and protein K11-linked ubiquitination. Predicted to be located in endoplasmic reticulum. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to human ASB11 (ankyrin repeat and SOCS box containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 25.8), genital fat pad adult (RPKM 17.3) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: X F5; X 76.53 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (163219976..163242166)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (164436953..164459170)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K11-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 11

Names: ASB-11; ankyrin repeat and SOCS box-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313737.1 → NP_001300666.1 ankyrin repeat and SOCS box protein 11 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK005404, BU757326

Consensus CDS

CCDS85827.1

UniProtKB/Swiss-Prot

A2AIH7, Q3UJ13, Q9CQ31, Q9D0V1

Related

ENSMUSP00000044637.5, ENSMUST00000036858.11

Conserved Domains (5) summary

cd00204
Location:66 → 183

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:102 → 189

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:66 → 118

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:66 → 95

ANK; ANK repeat [structural motif]

cl02533
Location:282 → 323

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
NM_026853.2 → NP_081129.1 ankyrin repeat and SOCS box protein 11 isoform 2

See identical proteins and their annotated locations for NP_081129.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK004396, AK005404, AK078851, BU757326

Consensus CDS

CCDS30523.1

UniProtKB/Swiss-Prot

Q9CQ31

Conserved Domains (3) summary

sd00045
Location:37 → 66

ANK; ANK repeat [structural motif]

cl02533
Location:253 → 294

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:33 → 240

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

163219976..163242166

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528972.5 → XP_006529035.2 ankyrin repeat and SOCS box protein 11 isoform X2

Conserved Domains (3) summary

sd00045
Location:66 → 95

ANK; ANK repeat [structural motif]

cl02533
Location:237 → 278

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:39 → 224

Ank_2; Ankyrin repeats (3 copies)
XM_006528971.5 → XP_006529034.2 ankyrin repeat and SOCS box protein 11 isoform X1

Conserved Domains (3) summary

PHA02874
Location:69 → 243

PHA02874; ankyrin repeat protein; Provisional

sd00045
Location:129 → 157

ANK; ANK repeat [structural motif]

cl02533
Location:246 → 287

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_036162086.1 → XP_036017979.1 ankyrin repeat and SOCS box protein 11 isoform X3

Related

ENSMUSP00000033755.6, ENSMUST00000033755.6

Conserved Domains (3) summary

sd00045
Location:37 → 66

ANK; ANK repeat [structural motif]

cl02533
Location:253 → 294

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:33 → 240

Ank_2; Ankyrin repeats (3 copies)
XM_030251494.2 → XP_030107354.1 ankyrin repeat and SOCS box protein 11 isoform X6

Conserved Domains (3) summary

sd00045
Location:37 → 66

ANK; ANK repeat [structural motif]

cl02533
Location:208 → 249

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:33 → 195

Ank_2; Ankyrin repeats (3 copies)
XM_036162087.1 → XP_036017980.1 ankyrin repeat and SOCS box protein 11 isoform X5

Conserved Domains (3) summary

PHA02874
Location:40 → 214

PHA02874; ankyrin repeat protein; Provisional

sd00045
Location:100 → 128

ANK; ANK repeat [structural motif]

cl02533
Location:217 → 258

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_006528974.5 → XP_006529037.1 ankyrin repeat and SOCS box protein 11 isoform X4

Conserved Domains (3) summary

sd00045
Location:30 → 59

ANK; ANK repeat [structural motif]

cl02533
Location:246 → 287

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:22 → 233

Ank_2; Ankyrin repeats (3 copies)