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    Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 [ Mus musculus (house mouse) ]

    Gene ID: 56445, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnaja2provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A2provided by MGI
    Primary source
    MGI:MGI:1931882
    See related
    Ensembl:ENSMUSG00000031701 AllianceGenome:MGI:1931882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DNAJ; DNJ3; mDj3; Dnaj3; HIRIP4; PRO3015; 1500017M13Rik; 2010206B19Rik
    Summary
    Predicted to enable ATPase activator activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in protein refolding. Predicted to be located in membrane. Predicted to be active in cytosol. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 23.5), placenta adult (RPKM 23.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnaja2 in Genome Data Viewer
    Location:
    8 C3; 8 41.61 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (86264262..86281990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85537633..85555361, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53446 Neighboring gene STARR-seq mESC enhancer starr_22160 Neighboring gene STARR-positive B cell enhancer ABC_E8255 Neighboring gene glutamic pyruvate transaminase (alanine aminotransferase) 2 Neighboring gene STARR-seq mESC enhancer starr_22166 Neighboring gene STARR-seq mESC enhancer starr_22168 Neighboring gene STARR-positive B cell enhancer ABC_E6669 Neighboring gene predicted gene, 51583 Neighboring gene STARR-seq mESC enhancer starr_22169 Neighboring gene predicted gene, 53447

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily A member 2
    Names
    DNA J protein
    DnaJ (Hsp40) homolog, subfamily A, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019794.5NP_062768.1  dnaJ homolog subfamily A member 2

      See identical proteins and their annotated locations for NP_062768.1

      Status: VALIDATED

      Source sequence(s)
      AC122409, AC130533
      Consensus CDS
      CCDS22500.1
      UniProtKB/Swiss-Prot
      Q9QYJ0
      UniProtKB/TrEMBL
      Q3TFF0
      Related
      ENSMUSP00000034138.6, ENSMUST00000034138.7
      Conserved Domains (1) summary
      PTZ00037
      Location:4412
      PTZ00037; DnaJ_C chaperone protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      86264262..86281990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)