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    Bpifb2 BPI fold containing family B, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 66557, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bpifb2provided by MGI
    Official Full Name
    BPI fold containing family B, member 2provided by MGI
    Primary source
    MGI:MGI:1913807
    See related
    Ensembl:ENSMUSG00000027481 AllianceGenome:MGI:1913807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RYSR; Bpil1; LPLUNC2; 2310034L21Rik; 2310069A01Rik
    Summary
    Predicted to enable lipid binding activity. Predicted to be located in extracellular region. Orthologous to human BPIFB2 (BPI fold containing family B member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 3.4), mammary gland adult (RPKM 1.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Bpifb2 in Genome Data Viewer
    Location:
    2 H1; 2 75.99 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153716925..153737190)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153875045..153895270)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 8 Neighboring gene translocase of outer mitochondrial membrane 20 homolog pseudogene Neighboring gene Sad1 and UNC84 domain containing 5 Neighboring gene BPI fold containing family B, member 6 Neighboring gene BPI fold containing family B, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and evolutionary analysis of the PLUNC gene family. Bingle CD, et al. Protein Sci, 2004 Feb. PMID 14739326, Free PMC Article
    2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. Bingle CD, et al. Biochem Soc Trans, 2011 Aug. PMID 21787333, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144836, MGC144837

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPI fold-containing family B member 2
    Names
    bactericidal/permeability-increasing protein-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025631.3 → NP_079907.2  BPI fold-containing family B member 2 precursor

      See identical proteins and their annotated locations for NP_079907.2

      Status: VALIDATED

      Source sequence(s)
      AK009776, AK010157, BC116681
      Consensus CDS
      CCDS16919.1
      UniProtKB/Swiss-Prot
      Q3TUY4, Q8BVZ0, Q8C1E1, Q8C1E2, Q9D713, Q9D744
      UniProtKB/TrEMBL
      Q14AS4, Q14AV3
      Related
      ENSMUSP00000028983.3, ENSMUST00000028983.3
      Conserved Domains (2) summary
      pfam01273
      Location:36 → 187
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
      cl00188
      Location:258 → 458
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      153716925..153737190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162459.1 → XP_036018352.1  BPI fold-containing family B member 2 isoform X3

      Conserved Domains (1) summary
      pfam01273
      Location:36 → 187
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

    2. XM_017319185.1 → XP_017174674.1  BPI fold-containing family B member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TUY4, Q8BVZ0, Q8C1E1, Q8C1E2, Q9D713, Q9D744
      UniProtKB/TrEMBL
      Q14AS4, Q14AV3
      Conserved Domains (2) summary
      pfam01273
      Location:36 → 187
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
      cl00188
      Location:258 → 458
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

    3. XM_006500007.1 → XP_006500070.1  BPI fold-containing family B member 2 isoform X2

      Conserved Domains (1) summary
      cl00188
      Location:46 → 246
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1E1.1 GenPept UniProtKB/Swiss-Prot:Q8C1E1

    Gene LinkOut

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