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    Supt20h SPT20 homolog, SAGA complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Supt20hprovided by RGD
    Official Full Name
    SPT20 homolog, SAGA complex componentprovided by RGD
    Primary source
    RGD:1307812
    See related
    EnsemblRapid:ENSRNOG00000059480 AllianceGenome:RGD:1307812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam48a; Supt20; RGD1307812
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of gluconeogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be part of SAGA complex. Orthologous to human SUPT20H (SPT20 homolog, SAGA complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 536.9), Thymus (RPKM 189.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Supt20h in Genome Data Viewer
    Location:
    2q26
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141047479..141080656)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (138897316..138930493)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (143892609..143925733)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 74 Neighboring gene transfer RNA alanine (anticodon GGC) Neighboring gene exosome component 8 Neighboring gene ALG5, dolichyl-phosphate beta-glucosyltransferase Neighboring gene SMAD family member 9 Neighboring gene uncharacterized LOC120100820

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. Ravnskjaer K, et al. J Clin Invest, 2013 Oct. PMID 24051374, Free PMC Article
    2. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
    3. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in gastrulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SAGA-type complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor SPT20 homolog
    Names
    family with sequence similarity 48, member A
    protein FAM48A
    suppressor of Ty 20
    transcription factor (p38 interacting protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395599.1 → NP_001382528.1  transcription factor SPT20 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2KAS5
      Conserved Domains (1) summary
      pfam12090
      Location:76 → 216
      Spt20; Spt20 family

    RNA

    1. NR_172645.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      141047479..141080656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760996.4 → XP_008759218.1  transcription factor SPT20 homolog isoform X10

      UniProtKB/TrEMBL
      A0A0G2KAS5
      Related
      ENSRNOP00000075507.3, ENSRNOT00000080443.3
      Conserved Domains (1) summary
      pfam12090
      Location:64 → 226
      Spt20; Spt20 family

    2. XM_006232338.5 → XP_006232400.1  transcription factor SPT20 homolog isoform X1

      See identical proteins and their annotated locations for XP_006232400.1

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    3. XM_039102603.2 → XP_038958531.1  transcription factor SPT20 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    4. XM_063282078.1 → XP_063138148.1  transcription factor SPT20 homolog isoform X10

      UniProtKB/TrEMBL
      A0A0G2KAS5

    5. XM_063282086.1 → XP_063138156.1  transcription factor SPT20 homolog isoform X16

      UniProtKB/TrEMBL
      A0A0G2KAS5

    6. XM_063282089.1 → XP_063138159.1  transcription factor SPT20 homolog isoform X17

      UniProtKB/TrEMBL
      A0A0G2KAS5
      Related
      ENSRNOP00000102278.1, ENSRNOT00000155166.1

    7. XM_039102608.2 → XP_038958536.1  transcription factor SPT20 homolog isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:60 → 200
      Spt20; Spt20 family

    8. XM_039102605.2 → XP_038958533.1  transcription factor SPT20 homolog isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    9. XM_039102612.2 → XP_038958540.1  transcription factor SPT20 homolog isoform X8

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (2) summary
      PHA03247
      Location:548 → 803
      PHA03247; large tegument protein UL36; Provisional
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    10. XM_039102611.2 → XP_038958539.1  transcription factor SPT20 homolog isoform X6

      UniProtKB/TrEMBL
      A0A0G2JYU8, A0A8I6G6T8
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    11. XM_039102613.2 → XP_038958541.1  transcription factor SPT20 homolog isoform X14

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    12. XM_063282082.1 → XP_063138152.1  transcription factor SPT20 homolog isoform X12

      UniProtKB/TrEMBL
      A0A0G2KAS5

    13. XM_008760998.4 → XP_008759220.1  transcription factor SPT20 homolog isoform X20

      UniProtKB/TrEMBL
      A0A0G2KAS5
      Conserved Domains (1) summary
      pfam12090
      Location:64 → 226
      Spt20; Spt20 family

    14. XM_063282091.1 → XP_063138161.1  transcription factor SPT20 homolog isoform X18

      UniProtKB/TrEMBL
      A0A0G2KAS5

    15. XM_039102614.2 → XP_038958542.1  transcription factor SPT20 homolog isoform X16

      UniProtKB/TrEMBL
      A0A0G2KAS5
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    16. XM_063282093.1 → XP_063138163.1  transcription factor SPT20 homolog isoform X22

      UniProtKB/TrEMBL
      A0A0G2KAS5

    17. XM_006232345.5 → XP_006232407.1  transcription factor SPT20 homolog isoform X2

      See identical proteins and their annotated locations for XP_006232407.1

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Related
      ENSRNOP00000100474.1, ENSRNOT00000136655.1
      Conserved Domains (1) summary
      pfam12090
      Location:76 → 216
      Spt20; Spt20 family

    18. XM_039102615.2 → XP_038958543.1  transcription factor SPT20 homolog isoform X9

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (2) summary
      PHA03247
      Location:547 → 802
      PHA03247; large tegument protein UL36; Provisional
      pfam12090
      Location:76 → 216
      Spt20; Spt20 family

    19. XM_063282075.1 → XP_063138145.1  transcription factor SPT20 homolog isoform X7

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Related
      ENSRNOP00000081981.2, ENSRNOT00000101018.2

    20. XM_063282084.1 → XP_063138154.1  transcription factor SPT20 homolog isoform X15

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Related
      ENSRNOP00000070797.3, ENSRNOT00000080026.3

    21. XM_063282083.1 → XP_063138153.1  transcription factor SPT20 homolog isoform X13

      UniProtKB/TrEMBL
      A0A0G2KAS5

    22. XM_008761000.4 → XP_008759222.1  transcription factor SPT20 homolog isoform X11

      UniProtKB/TrEMBL
      A0A0G2KAS5
      Conserved Domains (1) summary
      pfam12090
      Location:63 → 225
      Spt20; Spt20 family

    23. XM_008761001.4 → XP_008759223.1  transcription factor SPT20 homolog isoform X21

      UniProtKB/TrEMBL
      A0A0G2KAS5
      Conserved Domains (1) summary
      pfam12090
      Location:63 → 225
      Spt20; Spt20 family

    24. XM_063282092.1 → XP_063138162.1  transcription factor SPT20 homolog isoform X19

      UniProtKB/TrEMBL
      A0A0G2KAS5

    25. XM_063282094.1 → XP_063138164.1  transcription factor SPT20 homolog isoform X23

      UniProtKB/TrEMBL
      A0A0G2KAS5

    26. XM_039102606.2 → XP_038958534.1  transcription factor SPT20 homolog isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:60 → 200
      Spt20; Spt20 family

    27. XM_039102610.2 → XP_038958538.1  transcription factor SPT20 homolog isoform X5

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:59 → 199
      Spt20; Spt20 family

    28. XM_063282095.1 → XP_063138165.1  transcription factor SPT20 homolog isoform X24

      UniProtKB/TrEMBL
      A0A8I5ZMJ0

    29. XM_063282098.1 → XP_063138168.1  transcription factor SPT20 homolog isoform X25

      UniProtKB/Swiss-Prot
      Q66HC7
      UniProtKB/TrEMBL
      A0A8I5ZMJ0
      Related
      ENSRNOP00000078999.1, ENSRNOT00000099639.2

    30. XM_006232342.5 → XP_006232404.1  transcription factor SPT20 homolog isoform X1

      See identical proteins and their annotated locations for XP_006232404.1

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    31. XM_063282074.1 → XP_063138144.1  transcription factor SPT20 homolog isoform X6

      UniProtKB/TrEMBL
      A0A0G2JYU8, A0A8I6G6T8

    32. XM_063282077.1 → XP_063138147.1  transcription factor SPT20 homolog isoform X10

      UniProtKB/TrEMBL
      A0A0G2KAS5

    33. XM_063282085.1 → XP_063138155.1  transcription factor SPT20 homolog isoform X16

      UniProtKB/TrEMBL
      A0A0G2KAS5

    34. XM_063282096.1 → XP_063138166.1  transcription factor SPT20 homolog isoform X24

      UniProtKB/TrEMBL
      A0A8I5ZMJ0

    35. XM_063282081.1 → XP_063138151.1  transcription factor SPT20 homolog isoform X11

      UniProtKB/TrEMBL
      A0A0G2KAS5

    36. XM_063282080.1 → XP_063138150.1  transcription factor SPT20 homolog isoform X11

      UniProtKB/TrEMBL
      A0A0G2KAS5

    37. XM_063282088.1 → XP_063138158.1  transcription factor SPT20 homolog isoform X17

      UniProtKB/TrEMBL
      A0A0G2KAS5

    38. XM_063282097.1 → XP_063138167.1  transcription factor SPT20 homolog isoform X25

      UniProtKB/Swiss-Prot
      Q66HC7
      UniProtKB/TrEMBL
      A0A8I5ZMJ0

    39. XM_006232344.5 → XP_006232406.1  transcription factor SPT20 homolog isoform X1

      See identical proteins and their annotated locations for XP_006232406.1

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    40. XM_063282079.1 → XP_063138149.1  transcription factor SPT20 homolog isoform X10

      UniProtKB/TrEMBL
      A0A0G2KAS5

    41. XM_063282087.1 → XP_063138157.1  transcription factor SPT20 homolog isoform X16

      UniProtKB/TrEMBL
      A0A0G2KAS5

    42. XM_039102604.2 → XP_038958532.1  transcription factor SPT20 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:76 → 216
      Spt20; Spt20 family

    43. XM_063282090.1 → XP_063138160.1  transcription factor SPT20 homolog isoform X17

      UniProtKB/TrEMBL
      A0A0G2KAS5

    44. XM_006232346.5 → XP_006232408.1  transcription factor SPT20 homolog isoform X2

      See identical proteins and their annotated locations for XP_006232408.1

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:76 → 216
      Spt20; Spt20 family

    45. XM_063282076.1 → XP_063138146.1  transcription factor SPT20 homolog isoform X7

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Related
      ENSRNOP00000104405.1, ENSRNOT00000133542.1

    46. XM_039102609.2 → XP_038958537.1  transcription factor SPT20 homolog isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:60 → 200
      Spt20; Spt20 family

    47. XM_039102602.2 → XP_038958530.1  transcription factor SPT20 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYU8
      Conserved Domains (1) summary
      pfam12090
      Location:77 → 217
      Spt20; Spt20 family

    48. XM_063282073.1 → XP_063138143.1  transcription factor SPT20 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYU8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HC7.1 GenPept UniProtKB/Swiss-Prot:Q66HC7

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