Hmgb4 high-mobility group box 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmgb4provided by MGI
Official Full Name: high-mobility group box 4provided by MGI
Primary source: MGI:MGI:1916567
See related: Ensembl:ENSMUSG00000048686 AllianceGenome:MGI:1916567
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700001F22Rik
Summary: Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromosome and nucleus. Orthologous to human HMGB4 (high mobility group box 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 61.97 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (128154005..128154688, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (128260212..128260895, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In conclusion, the data suggest that HMGB4 is a factor that regulates chromatin and expression of neuronal differentiation markers.
Title: HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation.
Phe37 plays a critical role in stabilizing the binding complex of HMGB4 with the cisplatin-modified DNA.
Title: Binding interaction of HMGB4 with cisplatin-modified DNA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding, bending	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high mobility group protein B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027036.3 → NP_081312.2 high mobility group protein B4

See identical proteins and their annotated locations for NP_081312.2

Status: VALIDATED

Source sequence(s)

BC061030, CA465179, CN840046

Consensus CDS

CCDS18671.1

UniProtKB/Swiss-Prot

Q6P8W9, Q9DAR4

Related

ENSMUSP00000059625.4, ENSMUST00000053830.5

Conserved Domains (2) summary

cd00084
Location:93 → 156

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cl00082
Location:8 → 78

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...