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    Rnls renalase, FAD-dependent amine oxidase [ Mus musculus (house mouse) ]

    Gene ID: 67795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnlsprovided by MGI
    Official Full Name
    renalase, FAD-dependent amine oxidaseprovided by MGI
    Primary source
    MGI:MGI:1915045
    See related
    Ensembl:ENSMUSG00000071573 AllianceGenome:MGI:1915045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C10orf59; 6530404N21Rik
    Summary
    Enables oxidoreductase activity. Acts upstream of or within several processes, including catecholamine metabolic process; phosphate ion homeostasis; and response to norepinephrine. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human RNLS (renalase, FAD dependent amine oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Biased expression in testis adult (RPKM 47.5), adrenal adult (RPKM 5.9) and 7 other tissues See more
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    Genomic context

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    See Rnls in Genome Data Viewer
    Location:
    19 C1; 19 29.08 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33115140..33369695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (33137740..33392295, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29863 Neighboring gene predicted gene, 29946 Neighboring gene STARR-seq mESC enhancer starr_45963 Neighboring gene microRNA 3970 Neighboring gene STARR-positive B cell enhancer ABC_E11802 Neighboring gene predicted gene, 53225 Neighboring gene STARR-seq mESC enhancer starr_45967 Neighboring gene STARR-seq mESC enhancer starr_45968 Neighboring gene STARR-seq mESC enhancer starr_45969 Neighboring gene cullin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45970 Neighboring gene RIKEN cDNA 2810449D17 gene Neighboring gene STARR-seq mESC enhancer starr_45971 Neighboring gene STARR-seq mESC enhancer starr_45972 Neighboring gene predicted gene 7237 Neighboring gene STARR-seq mESC enhancer starr_45973 Neighboring gene 39S ribosomal protein L33, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Renalase mediates macrophage-to-fibroblast crosstalk to attenuate pressure overload-induced pathological myocardial fibrosis. Fu R, et al. J Hypertens, 2024 Apr 1. PMID 38230609
    2. Identification, expression and tissue distribution of a renalase homologue from mouse. Wang J, et al. Mol Biol Rep, 2008 Dec. PMID 17846919
    3. Renalase's expression and distribution in renal tissue and cells. Wang F, et al. PLoS One, 2012. PMID 23056310, Free PMC Article
    4. Renalase regulates peripheral and central dopaminergic activities. Quelhas-Santos J, et al. Am J Physiol Renal Physiol, 2015 Jan 15. PMID 25411385, Free PMC Article
    5. Denervation-induced muscle atrophy suppression in renalase-deficient mice via increased protein synthesis. Tokinoya K, et al. Physiol Rep, 2020 Aug. PMID 32741114, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renalase mediates macrophage-to-fibroblast crosstalk to attenuate pressure overload-induced pathological myocardial fibrosis.
      Title: Renalase mediates macrophage-to-fibroblast crosstalk to attenuate pressure overload-induced pathological myocardial fibrosis.
    2. Protective Renalase Deficiency in beta-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes.
      Title: Protective Renalase Deficiency in β-Cells Shapes Immune Metabolism and Function in Autoimmune Diabetes.
    3. Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model.
      Title: Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model.
    4. Data (including data from studies in knockout mice) suggest that renalase functions as a protective plasma protein that reduces pancreatic acinar cell injury and prevents pancreatitis via interactions with plasma membrane calcium ATPase Pmca4b.
      Title: The serum protein renalase reduces injury in experimental pancreatitis.
    5. High RNLS expression is associated with melanoma.
      Title: Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism.
    6. revealed renalase as a novel target gene of HIF-1alpha in protection against myocardial ischaemia/reperfusion injury
      Title: Renalase is a novel target gene of hypoxia-inducible factor-1 in protection against cardiac ischaemia-reperfusion injury.
    7. Renalase promotes cell survival and protects against renal injury in mice through the activation of intracellular signaling cascades, independent of its ability to metabolize catecholamines.
      Title: Renalase prevents AKI independent of amine oxidase activity.
    8. Renalase is wildly expressed in kidney, including glomeruli, tubule, mesangial cells, podocytes and tubule epithelial cells, and may be secreted by tubule epithelial cells primarily
      Title: Renalase's expression and distribution in renal tissue and cells.
    9. the identification of a renalase homologue from mouse, termed mMAO-C (mouse monoamine oxidase-C) after the monoamine oxidase-A and -B (MAO-A and -B
      Title: Identification, expression and tissue distribution of a renalase homologue from mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables epinephrine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac left ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within norepinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to norepinephrine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    renalase
    Names
    MAO-C
    alpha-NAD(P)H oxidase/anomerase
    monoamine oxidase-C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368833.1 → NP_001355762.1  renalase precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) represents the functional allele present in Kunming and other strains.
      Source sequence(s)
      AC125381, AC160088, DQ788834
      UniProtKB/Swiss-Prot
      A7RDN6, Q3TD88, Q80W75
      Conserved Domains (1) summary
      COG3380
      Location:1 → 342
      COG3380; Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]

    RNA

    1. NR_160911.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This transcript (1, non-coding) represents the non-coding allele present in the reference strain.
      Source sequence(s)
      AC117183, AC125381, AC160088
      Related
      ENSMUST00000096114.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      33115140..33369695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001146342.2: Suppressed sequence

      Description
      NM_001146342.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.

    2. NM_181587.2: Suppressed sequence

      Description
      NM_181587.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7RDN6.2 GenPept UniProtKB/Swiss-Prot:A7RDN6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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