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    Rnaset2a ribonuclease T2A [ Mus musculus (house mouse) ]

    Gene ID: 100037283, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnaset2aprovided by MGI
    Official Full Name
    ribonuclease T2Aprovided by MGI
    Primary source
    MGI:MGI:1915445
    See related
    Ensembl:ENSMUSG00000095687 AllianceGenome:MGI:1915445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnaset2; RNASE6PL; 0610007O07Rik; 4833423A10Rik; 4930532K22Rik
    Summary
    Predicted to enable RNA endonuclease activity. Predicted to be involved in RNA catabolic process. Predicted to be located in endoplasmic reticulum lumen; extracellular space; and lysosome. Predicted to be active in extracellular region. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 168.7), adrenal adult (RPKM 135.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnaset2a in Genome Data Viewer
    Location:
    17 A1; 17 4.87 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (8347412..8367078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (8128580..8148246, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1604A Neighboring gene predicted gene, 22416 Neighboring gene STARR-seq mESC enhancer starr_41760 Neighboring gene predicted gene, 41523 Neighboring gene STARR-positive B cell enhancer mm9_chr17:8358162-8358463 Neighboring gene STARR-positive B cell enhancer ABC_E7487 Neighboring gene centrosomal protein 43 Neighboring gene STARR-seq mESC enhancer starr_41762 Neighboring gene C-C motif chemokine receptor 6 Neighboring gene predicted gene, 33799

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Kettwig M, et al. Nat Commun, 2021 Nov 11. PMID 34764281, Free PMC Article
    2. Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies. Trubia M, et al. Genomics, 1997 Jun 1. PMID 9192857
    3. Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis. Zhang T, et al. Cell Signal, 2023 Nov. PMID 37633478
    4. An analysis of expression patterns of genes encoding proteins with catalytic activities. Cankaya M, et al. BMC Genomics, 2007 Jul 12. PMID 17626619, Free PMC Article
    5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
      Title: Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27782, MGC107248

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease T2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease T2-A
    Names
    ribonuclease 6
    ribonuclease 6-A
    ribonuclease T2
    NP_001077407.1
    NP_001351881.1
    NP_001351882.1
    NP_001351883.1
    XP_006523338.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083938.3 → NP_001077407.1  ribonuclease T2-A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001077407.1

      Status: VALIDATED

      Source sequence(s)
      AK018722, CJ214477
      Consensus CDS
      CCDS37433.1
      UniProtKB/Swiss-Prot
      C0HKG5, C0HKG6, Q9CQ01
      UniProtKB/TrEMBL
      Q5FWA0
      Related
      ENSMUSP00000095031.6, ENSMUST00000097420.7
      Conserved Domains (1) summary
      cd01061
      Location:39 → 221
      RNase_T2_euk; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

    2. NM_001364952.1 → NP_001351881.1  ribonuclease T2-A isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164314, AC168980
      Conserved Domains (1) summary
      cl00208
      Location:39 → 184
      RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

    3. NM_001364953.1 → NP_001351882.1  ribonuclease T2-A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164314, AC168980
      UniProtKB/TrEMBL
      A0A338P711
      Conserved Domains (1) summary
      pfam00445
      Location:2 → 127
      Ribonuclease_T2; Ribonuclease T2 family

    4. NM_001364954.1 → NP_001351883.1  ribonuclease T2-A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC164314, AC168980
      UniProtKB/TrEMBL
      A0A338P711, A0A338P7E3
      Conserved Domains (1) summary
      cl00208
      Location:1 → 125
      RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      8347412..8367078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523275.3 → XP_006523338.1  ribonuclease T2-A isoform X1

      UniProtKB/TrEMBL
      A0A338P711
      Conserved Domains (1) summary
      pfam00445
      Location:2 → 127
      Ribonuclease_T2; Ribonuclease T2 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HKG5.1 GenPept UniProtKB/Swiss-Prot:C0HKG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials
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