Zp2 zona pellucida glycoprotein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zp2provided by RGD
Official Full Name: zona pellucida glycoprotein 2provided by RGD
Primary source: RGD:620605
See related: EnsemblRapid:ENSRNOG00000057989 AllianceGenome:RGD:620605
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zp-2
Summary: Predicted to enable acrosin binding activity and identical protein binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida; humoral immune response mediated by circulating immunoglobulin; and prevention of polyspermy. Predicted to be located in several cellular components, including endoplasmic reticulum; inclusion body; and multivesicular body. Predicted to be active in collagen-containing extracellular matrix and egg coat. Orthologous to human ZP2 (zona pellucida glycoprotein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 8.9), Uterus (RPKM 6.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (183944840..183956619, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (174513507..174525288, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (189899906..189911650, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acrosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables acrosin binding	IEA Inferred from Electronic Annotation more info
enables acrosin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of egg coat	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of egg coat	IEA Inferred from Electronic Annotation more info
enables structural constituent of egg coat	ISO Inferred from Sequence Orthology more info
enables structural constituent of egg coat	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in prevention of polyspermy	IBA Inferred from Biological aspect of Ancestor more info
involved_in prevention of polyspermy	IEA Inferred from Electronic Annotation more info
involved_in prevention of polyspermy	ISO Inferred from Sequence Orthology more info
involved_in prevention of polyspermy	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT involved_in regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in egg coat	IBA Inferred from Biological aspect of Ancestor more info
located_in egg coat	IEA Inferred from Electronic Annotation more info
located_in egg coat	ISO Inferred from Sequence Orthology more info
located_in egg coat	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zona pellucida sperm-binding protein 2

Names: zona pellucida 2 glycoprotein; zona pellucida glycoprotein 2 (sperm receptor); zona pellucida glycoprotein ZP2; zona pellucida protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031150.1 → NP_112412.1 zona pellucida sperm-binding protein 2 precursor

See identical proteins and their annotated locations for NP_112412.1

Status: PROVISIONAL

Source sequence(s)

AB000929

UniProtKB/Swiss-Prot

O54767

UniProtKB/TrEMBL

A6I8Q0, M0R4S4

Related

ENSRNOP00000110682.1, ENSRNOT00000136473.1

Conserved Domains (2) summary

smart00241
Location:354 → 614

ZP; Zona pellucida (ZP) domain

pfam00100
Location:481 → 614

Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

183944840..183956619 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092370.2 → XP_038948298.1 zona pellucida sperm-binding protein 2 isoform X1

Conserved Domains (1) summary

smart00241
Location:22 → 282

ZP; Zona pellucida (ZP) domain