Slc5a3 solute carrier family 5 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc5a3provided by RGD
Official Full Name: solute carrier family 5 member 3provided by RGD
Primary source: RGD:621530
See related: EnsemblRapid:ENSRNOG00000067988 AllianceGenome:RGD:621530
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Smit
Summary: Predicted to enable several functions, including monosaccharide transmembrane transporter activity; myo-inositol:sodium symporter activity; and transmembrane transporter binding activity. Predicted to be involved in monosaccharide transmembrane transport; polyol transmembrane transport; and regulation of transporter activity. Predicted to act upstream of or within several processes, including inositol metabolic process; myo-inositol transport; and positive regulation of reactive oxygen species biosynthetic process. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and perinuclear region of cytoplasm. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human SLC5A3 (solute carrier family 5 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (44799787..44802233)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (31313847..31316293)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (32229366..32231812)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates Arterial Contractility Through the Modulation of Vascular Kv7 Channels.
Title: SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates Arterial Contractility Through the Modulation of Vascular Kv7 Channels.
Results indicate that H(+)/myo-inositol cotransporter (HMIT) is expressed in marginal cells and basal cells of the stria vascularis, while Na(+)/myo-inositol cotransporter 1 (SMIT1) expression is enriched in basal cells. Study speculates that HMIT and SMIT1 may play important roles in the homeostasis of cochlear fluids.
Title: Differential localizations of the myo-inositol transporters HMIT and SMIT1 in the cochlear stria vascularis.
Myo-inositol transporter SMIT1 is required to maintain a stable phosphoinositide pool in beta-cells in order that phosphoinositide remains available despite its rapid turnover.
Title: Identification and Functional Implications of Sodium/Myo-Inositol Cotransporter 1 in Pancreatic β-Cells and Type 2 Diabetes.
Intracerebral hemorrhage upregulates Na(+)/myo-inositol cotransporter in the rat brain.
Title: Intracerebral hemorrhage upregulates Na(+)/myo-inositol cotransporter in the rat brain.
Basolateral Na+-MI cotransporter activity is maximal at physiological pH values of MTAL cells and interstitium, and a powerful modulation of the transporter activity may be exerted by pHe and pHi.
Title: pH dependence of Na+/myo-inositol cotransporters in rat thick limb cells.

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General gene information

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Markers

BI279882 (e-PCR)
- UniSTS:245047

UniSTS:259143 (e-PCR)
- UniSTS:259143

Slc5a3 (e-PCR), detects polymorphism
- UniSTS:259143

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables D-glucose:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables fucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables myo-inositol:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables pentose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables polyol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in fucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in hexose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in myo-inositol transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myo-inositol transport	ISO Inferred from Sequence Orthology more info
involved_in myo-inositol transport	ISO Inferred from Sequence Orthology more info
involved_in pentose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system development	ISO Inferred from Sequence Orthology more info
involved_in polyol transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein localization to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
involved_in regulation of transporter activity	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/myo-inositol cotransporter

Names: solute carrier family 5 (inositol transporters), member 3; solute carrier family 5 (sodium/myo-inositol cotransporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.