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    Tagln3 transgelin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63837, updated on 27-Nov-2024

    Summary

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    Symbol
    Tagln3provided by RGD
    Full Name
    transgelin 3provided by RGD
    Primary source
    RGD:69301
    See related
    EnsemblRapid:ENSRNOG00000064186 AllianceGenome:RGD:69301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Np22; Np25
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in actin cytoskeleton and synapse. Orthologous to human TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 974.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tagln3 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (68562482..68576058)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55099887..55113457)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60072983..60086552)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain, family B, member 2 Neighboring gene small nucleolar RNA U13 Neighboring gene abhydrolase domain containing 10, depalmitoylase Neighboring gene transmembrane serine protease 7 Neighboring gene similar to human chromosome 3 open reading frame 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The novel cytoskeleton-associated protein Neuronal protein 22: elevated expression in the developing rat brain. Depaz IM, et al. Brain Res, 2006 Apr 7. PMID 16542643
    2. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. Fan L, et al. J Neurochem, 2001 Mar. PMID 11238712
    3. The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations. Ren WZ, et al. Brain Res Mol Brain Res, 1994 Mar. PMID 8015377
    4. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Feng J, et al. Biol Reprod, 2008 Sep. PMID 18480465, Free PMC Article
    5. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transgelin-3
    Names
    neuronal protein 22
    neuronal protein Np25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035236.1 → NP_001030313.1  transgelin-3

      See identical proteins and their annotated locations for NP_001030313.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF459788, M84725
      UniProtKB/Swiss-Prot
      P37805, Q09025, Q8VHH3
      UniProtKB/TrEMBL
      A0A8L2UHL4, A6IQX9
      Related
      ENSRNOP00000072985.1, ENSRNOT00000090230.3
      Conserved Domains (2) summary
      pfam00402
      Location:174 → 198
      Calponin; Calponin family repeat
      cd21281
      Location:23 → 141
      CH_TAGLN3; calponin homology (CH) domain found in transgelin-3

    2. NM_031676.2 → NP_113864.2  transgelin-3

      See identical proteins and their annotated locations for NP_113864.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF459788, CB795348, M84725
      UniProtKB/Swiss-Prot
      P37805, Q09025, Q8VHH3
      UniProtKB/TrEMBL
      A0A8L2UHL4, A6IQX9
      Conserved Domains (2) summary
      pfam00402
      Location:174 → 198
      Calponin; Calponin family repeat
      cd21281
      Location:23 → 141
      CH_TAGLN3; calponin homology (CH) domain found in transgelin-3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      68562482..68576058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088610.2 → XP_038944538.1  transgelin-3 isoform X1

      Conserved Domains (2) summary
      pfam00402
      Location:90 → 114
      Calponin; Calponin family repeat
      cl00030
      Location:1 → 70
      CH_SF; calponin homology (CH) domain superfamily

    2. XM_039088609.2 → XP_038944537.1  transgelin-3 isoform X1

      Conserved Domains (2) summary
      pfam00402
      Location:90 → 114
      Calponin; Calponin family repeat
      cl00030
      Location:1 → 70
      CH_SF; calponin homology (CH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37805.2 GenPept UniProtKB/Swiss-Prot:P37805

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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