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    Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63845, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmeff1provided by RGD
    Official Full Name
    transmembrane protein with EGF-like and two follistatin-like domains 1provided by RGD
    Primary source
    RGD:62005
    See related
    EnsemblRapid:ENSRNOG00000008034 AllianceGenome:RGD:62005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including TMEFF1 (transmembrane protein with EGF like and two follistatin like domains 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 214.2), Lung (RPKM 94.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmeff1 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (67706269..67792022)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (62910740..62996494)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (64326733..64412531)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene inversin Neighboring gene testis expressed 10 Neighboring gene uncharacterized LOC108350968 Neighboring gene Myb/SANT DNA binding domain containing 3 Neighboring gene caveolae associated protein 4 Neighboring gene uncharacterized LOC134487066

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMEFF1 and brain tumors. Gery S, et al. Oncogene, 2003 May 8. PMID 12743596
    2. Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development. Eib DW, et al. Mech Dev, 2000 Oct. PMID 11025219
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor ligand inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor ligand inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral entry into host cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tomoregulin-1
    Names
    TR-1
    transmembrane protein with EGF-like and one follistatin-like domain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429960.1 → NP_001416889.1  tomoregulin-1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A3D5

    2. NM_023020.3 → NP_075409.1  tomoregulin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_075409.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9QYV1
      UniProtKB/TrEMBL
      A0A8I5Y818
      Related
      ENSRNOP00000063443.2, ENSRNOT00000065775.4
      Conserved Domains (2) summary
      PHA02887
      Location:268 → 304
      PHA02887; EGF-like protein; Provisional
      smart00280
      Location:92 → 136
      KAZAL; Kazal type serine protease inhibitors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      67706269..67792022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110701.2 → XP_038966629.1  tomoregulin-1 isoform X1

      Related
      ENSRNOP00000103683.1, ENSRNOT00000136411.1
      Conserved Domains (3) summary
      PHA02887
      Location:268 → 304
      PHA02887; EGF-like protein; Provisional
      PHA03099
      Location:268 → 355
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00280
      Location:92 → 136
      KAZAL; Kazal type serine protease inhibitors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYV1.1 GenPept UniProtKB/Swiss-Prot:Q9QYV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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