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    Mx2 MX dynamin like GTPase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286918, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mx2provided by RGD
    Official Full Name
    MX dynamin like GTPase 2provided by RGD
    Primary source
    RGD:628821
    See related
    EnsemblRapid:ENSRNOG00000001963 AllianceGenome:RGD:628821
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mx3
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and microtubule binding activity. Involved in response to virus. Located in cytoplasm. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 127.4), Lung (RPKM 94.9) and 8 other tissues See more
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    Genomic context

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    See Mx2 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50375101..50399373)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (36905698..36936308)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38035306..38066185)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene MX dynamin like GTPase 1 Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene uncharacterized LOC134480979 Neighboring gene transmembrane serine protease 2 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Antiviral determinants of rat Mx GTPases map to the carboxy-terminal half. Johannes L, et al. J Virol, 1997 Dec. PMID 9371647, Free PMC Article
    2. Activity of rat Mx proteins against a rhabdovirus. Meier E, et al. J Virol, 1990 Dec. PMID 2173790, Free PMC Article
    3. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Rennie ML, et al. Structure, 2014 Oct 7. PMID 25295396
    4. In vitro inhibition of the replication of classical swine fever virus by porcine Mx1 protein. He DN, et al. Antiviral Res, 2014 Apr. PMID 24500530
    5. Inhibition of Dugbe nairovirus replication by human MxA protein. Bridgen A, et al. Virus Res, 2004 Jan. PMID 14687945

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
      Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to type I interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of intracellular transport of viral material ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced GTP-binding protein Mx2
    Names
    interferon-induced GTP-binding protein Mx3
    myxovirus (influenza virus) resistance 2
    myxovirus (influenza virus) resistance 3
    myxovirus resistance protein 2
    myxovirus resistance protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134350.2 → NP_599177.2  interferon-induced GTP-binding protein Mx2

      See identical proteins and their annotated locations for NP_599177.2

      Status: PROVISIONAL

      Source sequence(s)
      BC099808
      UniProtKB/TrEMBL
      A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3
      Related
      ENSRNOP00000075302.3, ENSRNOT00000083067.3
      Conserved Domains (3) summary
      cd08771
      Location:66 → 338
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:258 → 544
      Dynamin_M; Dynamin central region
      pfam02212
      Location:569 → 657
      GED; Dynamin GTPase effector domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      50375101..50399373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088055.2 → XP_038943983.1  interferon-induced GTP-binding protein Mx2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3
      Conserved Domains (3) summary
      cd08771
      Location:66 → 338
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:258 → 544
      Dynamin_M; Dynamin central region
      pfam02212
      Location:569 → 657
      GED; Dynamin GTPase effector domain

    2. XM_063270316.1 → XP_063126386.1  interferon-induced GTP-binding protein Mx2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAR4, A6IQG6, Q499Q3
      Related
      ENSRNOP00000075496.1, ENSRNOT00000087603.3

    3. XM_063270317.1 → XP_063126387.1  interferon-induced GTP-binding protein Mx2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAR4, A6IQG6, Q499Q3

    4. XM_063270318.1 → XP_063126388.1  interferon-induced GTP-binding protein Mx2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAR4, A6IQG6, Q499Q3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18589.1 GenPept UniProtKB/Swiss-Prot:P18589
    P18590.1 GenPept UniProtKB/Swiss-Prot:P18590

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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