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    Meg3 maternally expressed 3 [ Mus musculus (house mouse) ]

    Gene ID: 17263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Meg3provided by MGI
    Official Full Name
    maternally expressed 3provided by MGI
    Primary source
    MGI:MGI:1202886
    See related
    Ensembl:ENSMUSG00000021268 AllianceGenome:MGI:1202886
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtl2; D12Bwg1266e; 2900016C05Rik; 3110050O07Rik; 6330408G06Rik
    Summary
    This gene is paternally-imprinted and thus expressed predominantly from the maternal allele. It generates alternatively-spliced long non protein-coding RNAs that overlap with the microRNAs Mir770 and Mir1906-1. Transcripts from this gene function as negative regulators of growth and may be down-regulated in tumor cells. This gene is expressed in a reciprocal pattern from the nearby Dlk1 (delta-like 1 homolog) gene, which is paternally-expressed. Deletion of this locus disrupts imprinting in this genomic region and results in perinatal morbidity. [provided by RefSeq, Dec 2013]
    Expression
    Broad expression in limb E14.5 (RPKM 360.3), frontal lobe adult (RPKM 253.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Meg3 in Genome Data Viewer
    Location:
    12 F1; 12 60.25 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (109506879..109538163)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (109540996..109571729)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene delta like non-canonical Notch ligand 1 Neighboring gene predicted gene, 34081 Neighboring gene VISTA enhancer mm799 Neighboring gene predicted gene, 34017 Neighboring gene microRNA 1906-1 Neighboring gene microRNA 770 Neighboring gene retrotransposon Gaglike 1 Neighboring gene microRNA 673 Neighboring gene microRNA 493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CREB-upregulated lncRNA MEG3 promotes hepatic gluconeogenesis by regulating miR-302a-3p-CRTC2 axis. Zhu X, et al. J Cell Biochem, 2019 Mar. PMID 30260029
    2. ICR noncoding RNA expression controls imprinting and DNA replication at the Dlk1-Dio3 domain. Kota SK, et al. Dev Cell, 2014 Oct 13. PMID 25263792
    3. Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell. Kitagawa A, et al. J Smooth Muscle Res, 2022. PMID 35491127, Free PMC Article
    4. LncRNA MEG3 regulates autophagy and pyroptosis via FOXO1 in pancreatic β-cells. Li X, et al. Cell Signal, 2022 Apr. PMID 35101568
    5. Mechanism of M2 macrophage-derived extracellular vesicles carrying lncRNA MEG3 in inflammatory responses in ulcerative colitis. Wang YX, et al. Bioengineered, 2021 Dec. PMID 34895044, Free PMC Article

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunction.
      Title: Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunction.
    2. GNAS mutations suppress cell invasion by activating MEG3 in growth hormone-secreting pituitary adenoma.
      Title: GNAS mutations suppress cell invasion by activating MEG3 in growth hormone-secreting pituitary adenoma.
    3. m[6]A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis.
      Title: m(6)A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis.
    4. Transgenerational epigenetic self-memory of Dio3 dosage is associated with Meg3 methylation and altered growth trajectories and neonatal hormones.
      Title: Transgenerational epigenetic self-memory of Dio3 dosage is associated with Meg3 methylation and altered growth trajectories and neonatal hormones.
    5. Multifaceted roles of Meg3 in cellular senescence and atherosclerosis.
      Title: Multifaceted roles of Meg3 in cellular senescence and atherosclerosis.
    6. Upregulated LncRNA-Meg3 modulates the proliferation and survival of MEPM cells via interacting with Smad signaling in TCDD-induced cleft palate.
      Title: Upregulated LncRNA-Meg3 modulates the proliferation and survival of MEPM cells via interacting with Smad signaling in TCDD-induced cleft palate.
    7. The long non-coding RNA Meg3 mediates imprinted gene expression during stem cell differentiation.
      Title: The long non-coding RNA Meg3 mediates imprinted gene expression during stem cell differentiation.
    8. The lncRNA MEG3/miRNA-21/P38MAPK axis inhibits coxsackievirus 3 replication in acute viral myocarditis.
      Title: The lncRNA MEG3/miRNA-21/P38MAPK axis inhibits coxsackievirus 3 replication in acute viral myocarditis.
    9. LncRNA MEG3 aggravates adipocyte inflammation and insulin resistance by targeting IGF2BP2 to activate TLR4/NF-kappaB signaling pathway.
      Title: LncRNA MEG3 aggravates adipocyte inflammation and insulin resistance by targeting IGF2BP2 to activate TLR4/NF-κB signaling pathway.
    10. Inhibition of MEG3 ameliorates cardiomyocyte apoptosis and autophagy by regulating the expression of miRNA-129-5p in a mouse model of heart failure.
      Title: Inhibition of MEG3 ameliorates cardiomyocyte apoptosis and autophagy by regulating the expression of miRNA-129-5p in a mouse model of heart failure.
    Submit: New GeneRIF Correction See all GeneRIFs (91)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Other Names

    • GTL2, imprinted maternally expressed untranslated mRNA
    • gene trap locus 2
    • maternally expressed gene 3

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epigenetic programing of female pronucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within genomic imprinting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within genomic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003633.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks multiple 5' exons and differs in the 5' terminal exon, resulting in a longer transcript, compared to variant 2.
      Source sequence(s)
      AC152063, AK018105, AK147321, BE992865

    2. NR_027651.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents variant 2.
      Source sequence(s)
      AC152063, AK018105, AK147321, BC094421, BE992865, BY134134

    3. NR_027652.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate exon in the 5' region and differs in the 3' terminal exon, resulting in a shorter transcript, compared to variant 2.
      Source sequence(s)
      BC024818, BY134134, Y13832
      Related
      ENSMUST00000143836.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      109506879..109538163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144513.2: Suppressed sequence

      Description
      NM_144513.2: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.

    2. NR_046475.1: Suppressed sequence

      Description
      NR_046475.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

    3. NR_104450.1: Suppressed sequence

      Description
      NR_104450.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

    4. NR_104451.1: Suppressed sequence

      Description
      NR_104451.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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