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    Wdr53 WD repeat domain 53 [ Mus musculus (house mouse) ]

    Gene ID: 68980, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wdr53provided by MGI
    Official Full Name
    WD repeat domain 53provided by MGI
    Primary source
    MGI:MGI:1916230
    See related
    Ensembl:ENSMUSG00000022787 AllianceGenome:MGI:1916230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500002B03Rik
    Summary
    Orthologous to human WDR53 (WD repeat domain 53). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 11.0), CNS E11.5 (RPKM 4.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr53 in Genome Data Viewer
    Location:
    16 B2; 16 22.47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32066047..32075901)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32247227..32257085)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene brain expressed family member 6 Neighboring gene STARR-seq mESC enhancer starr_40648 Neighboring gene STARR-seq mESC enhancer starr_40649 Neighboring gene F-box protein 45 Neighboring gene STARR-positive B cell enhancer ABC_E10901 Neighboring gene predicted gene, 25848 Neighboring gene STARR-positive B cell enhancer ABC_E4166 Neighboring gene microRNA 1946a Neighboring gene single-pass membrane protein with coiled-coil domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Rutkowski TP, et al. Mol Psychiatry, 2021 Mar. PMID 30976085, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185162.2 → NP_001172091.1  WD repeat-containing protein 53

      See identical proteins and their annotated locations for NP_001172091.1

      Status: VALIDATED

      Source sequence(s)
      AC126265
      Consensus CDS
      CCDS28118.1
      UniProtKB/Swiss-Prot
      Q9DB94
      Related
      ENSMUSP00000135908.2, ENSMUST00000178573.8
      Conserved Domains (3) summary
      COG2319
      Location:237 → 358
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 49
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:8 → 269
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001399294.1 → NP_001386223.1  WD repeat-containing protein 53

      Status: VALIDATED

      Source sequence(s)
      AC126265
      UniProtKB/Swiss-Prot
      Q9DB94
      Conserved Domains (3) summary
      COG2319
      Location:237 → 358
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 49
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:8 → 269
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_026898.3 → NP_081174.1  WD repeat-containing protein 53

      See identical proteins and their annotated locations for NP_081174.1

      Status: VALIDATED

      Source sequence(s)
      AC126265
      Consensus CDS
      CCDS28118.1
      UniProtKB/Swiss-Prot
      Q9DB94
      Related
      ENSMUSP00000023474.4, ENSMUST00000023474.4
      Conserved Domains (3) summary
      COG2319
      Location:237 → 358
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 49
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:8 → 269
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32066047..32075901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB94.1 GenPept UniProtKB/Swiss-Prot:Q9DB94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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