Dlgap3 DLG associated protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dlgap3provided by MGI
Official Full Name: DLG associated protein 3provided by MGI
Primary source: MGI:MGI:3039563
See related: Ensembl:ENSMUSG00000042388 AllianceGenome:MGI:3039563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DAP3; DAP-3; Prpl8; Sapap3
Summary: Enables amyloid-beta binding activity. Involved in modification of postsynaptic structure and modulation of chemical synaptic transmission. Located in synapse. Is active in several cellular components, including cholinergic synapse; glutamatergic synapse; and neuromuscular junction. Is expressed in corpus striatum. Orthologous to human DLGAP3 (DLG associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 35.9), frontal lobe adult (RPKM 29.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 61.33 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (127062090..127130815)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (127168305..127237022)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Experience-dependent grooming microstructure alterations and gastrointestinal dysfunction in the SAPAP3 knockout mouse model of compulsive behaviour.
Title: Experience-dependent grooming microstructure alterations and gastrointestinal dysfunction in the SAPAP3 knockout mouse model of compulsive behaviour.
Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior.
Title: Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior.
Valence processing alterations in SAPAP3 knockout mice and human OCD.
Title: Valence processing alterations in SAPAP3 knockout mice and human OCD.
SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities.
Title: SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities.
Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice.
Title: Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice.
Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder.
Title: Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder.
Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice.
Title: Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice.
Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice.
Title: Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice.
Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [(11)C]ABP688 PET study.
Title: Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [(11)C]ABP688 PET study.
Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder.
Title: Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic structure	IEP Inferred from Expression Pattern more info	PubMed
involved_in modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cholinergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IEP Inferred from Expression Pattern more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization	IEP Inferred from Expression Pattern more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disks large-associated protein 3

Names: PSD-95/SAP90-binding protein 3; SAP90/PSD 95 associated protein 3; discs, large homolog-associated protein 3; prion protein ligand 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302081.2 → NP_001289010.1 disks large-associated protein 3 isoform 1

See identical proteins and their annotated locations for NP_001289010.1

Status: VALIDATED

Source sequence(s)

AL606984

Consensus CDS

CCDS18665.1

UniProtKB/Swiss-Prot

Q6PDX0, Q6PFD5, Q6XBF2

UniProtKB/TrEMBL

Q3TY61

Related

ENSMUSP00000101700.3, ENSMUST00000106094.9

Conserved Domains (2) summary

PHA03418
Location:515 → 607

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:626 → 977

GKAP; Guanylate-kinase-associated protein (GKAP) protein
NM_001426291.1 → NP_001413220.1 disks large-associated protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

AL606984

UniProtKB/Swiss-Prot

Q6PDX0, Q6PFD5, Q6XBF2

UniProtKB/TrEMBL

Q3TY61
NM_001426292.1 → NP_001413221.1 disks large-associated protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

AL606984

UniProtKB/Swiss-Prot

Q6PDX0, Q6PFD5, Q6XBF2

UniProtKB/TrEMBL

Q3TY61
NM_001426293.1 → NP_001413222.1 disks large-associated protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AL606984

UniProtKB/TrEMBL

B1AS06

Related

ENSMUSP00000101698.2, ENSMUST00000106092.2
NM_001426294.1 → NP_001413223.1 disks large-associated protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AL606984

UniProtKB/TrEMBL

B1AS06
NM_001426295.1 → NP_001413224.1 disks large-associated protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AL606984
NM_198618.6 → NP_941020.1 disks large-associated protein 3 isoform 1

See identical proteins and their annotated locations for NP_941020.1

Status: VALIDATED

Source sequence(s)

AL606984

Consensus CDS

CCDS18665.1

UniProtKB/Swiss-Prot

Q6PDX0, Q6PFD5, Q6XBF2

UniProtKB/TrEMBL

Q3TY61

Related

ENSMUSP00000039724.8, ENSMUST00000046659.14

Conserved Domains (2) summary

PHA03418
Location:515 → 607

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:626 → 977

GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

127062090..127130815

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164130.1 → XP_036020023.1 disks large-associated protein 3 isoform X1

UniProtKB/Swiss-Prot

Q6PDX0, Q6PFD5, Q6XBF2

UniProtKB/TrEMBL

Q3TY61

Conserved Domains (2) summary

PHA03418
Location:515 → 607

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:626 → 977

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_011240537.3 → XP_011238839.1 disks large-associated protein 3 isoform X1

See identical proteins and their annotated locations for XP_011238839.1

UniProtKB/Swiss-Prot

Q6PDX0, Q6PFD5, Q6XBF2

UniProtKB/TrEMBL

Q3TY61

Conserved Domains (2) summary

PHA03418
Location:515 → 607

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:626 → 977

GKAP; Guanylate-kinase-associated protein (GKAP) protein